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Titolo:
Effects of ecstasy (MDMA) on the brain in abstinent users: Initial observations with diffusion and perfusion MR imaging
Autore:
Reneman, L; Majoie, CBLM; Habraken, JBA; den Heeten, GJ;
Indirizzi:
Univ Amsterdam, Acad Med Ctr, Grad Sch Neurosci, Dept Nucl Med, NL-1105 AZAmsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ AZAmsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Radiol, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands
Titolo Testata:
RADIOLOGY
fascicolo: 3, volume: 220, anno: 2001,
pagine: 611 - 617
SICI:
0033-8419(200109)220:3<611:EOE(OT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-VOLUME; CENTRAL SEROTONERGIC NEURONS; MULTIPLE-SCLEROSIS; RAT-BRAIN; NONHUMAN-PRIMATES; WATER DIFFUSION; ACUTE STROKE; 3,4-METHYLENEDIOXYMETHAMPHETAMINE; NEUROTOXICITY; RECOVERY;
Keywords:
brain, effects of drugs on; drugs, abuse; magnetic resonance (MR), diffusion study; magnetic resonance (MR), perfusion study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Reneman, L Univ Amsterdam, Acad Med Ctr, Grad Sch Neurosci, Dept Nucl Med,Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Meibergdreef 9 Amsterdam Netherlands NL-1105 AZ
Citazione:
L. Reneman et al., "Effects of ecstasy (MDMA) on the brain in abstinent users: Initial observations with diffusion and perfusion MR imaging", RADIOLOGY, 220(3), 2001, pp. 611-617

Abstract

PURPOSE: To evaluate the effects of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) on the human brain by using diffusion and perfusion magnetic resonance (MR) imaging. MATERIALS AND METHODS: Eight abstinent ecstasy users and six ecstasy nonusers underwent diffusion and perfusion MR imaging. Apparent diffusion coefficient and relative cerebral volume maps were reconstructed. Differences in apparent diffusion coefficient values and relative cerebral volume ratios between the groups were analyzed with the Mann-Whitney-Wilcoxon test. The relationship between apparent diffusion coefficient and relative cerebral volume and the extent of previous ecstasy use was investigated with Spearman rank correlation. RESULTS: Apparent diffusion coefficient values (0.84 vs 0.65 X 10(-5) cm(2)/sec, P < .025) and relative cerebral volume ratios (1.22 vs 1.01, P < .025) were significantly higher in the globus pallidus of ecstasy users compared with nonusers, respectively. Increases in pallidal relative cerebral volume were positively correlated with the extent of previous use of ecstasy (rho = 0.73, P < .04). CONCLUSION: Ecstasy use is associated with tissue changes in the globus pallidus. These findings are in agreement with findings in case reports, suggesting that the globus pallidus is particularly sensitive to the effects ofecstasy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:14:32