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Titolo:
Effect of a cysteinyl leukotriene antagonist, pranlukast hydrate, on acetaldehyde-induced bronchoconstriction in asthmatic patients
Autore:
Myou, S; Fujimura, M; Kamio, Y; Kita, T; Katayama, N; Abo, M; Yoshimi, Y; Nishitsuji, M; Nomura, S; Hashimoto, T; Nakao, S;
Indirizzi:
Kanazawa Univ, Sch Med, Dept Internal Med 3, Kanazawa, Ishikawa 920, JapanKanazawa Univ Kanazawa Ishikawa Japan 920 , Kanazawa, Ishikawa 920, Japan Kanazawa Univ Hosp, Cent Lab, Kanazawa, Ishikawa, Japan Kanazawa Univ Hosp Kanazawa Ishikawa Japan ab, Kanazawa, Ishikawa, Japan Kanazawa Univ, Sch Med, Dept Lab Med, Kanazawa, Ishikawa 920, Japan Kanazawa Univ Kanazawa Ishikawa Japan 920 , Kanazawa, Ishikawa 920, Japan
Titolo Testata:
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
fascicolo: 1, volume: 65, anno: 2001,
pagine: 41 - 44
SICI:
0952-3278(200107)65:1<41:EOACLA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
HISTAMINE-MEDIATED BRONCHOCONSTRICTION; RECEPTOR ANTAGONIST; BRONCHIAL HYPERRESPONSIVENESS; AEROSOLIZED ACETALDEHYDE; AIRWAY RESPONSIVENESS; GUINEA-PIGS; METHACHOLINE; INHIBITION; ONO-1078;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Myou, S 020 S Lake Shore Dr 1010-N, Chicago, IL 60615 USA 020 S Lake Shore Dr 1010-N Chicago IL USA 60615 ago, IL 60615 USA
Citazione:
S. Myou et al., "Effect of a cysteinyl leukotriene antagonist, pranlukast hydrate, on acetaldehyde-induced bronchoconstriction in asthmatic patients", PROS LEUK E, 65(1), 2001, pp. 41-44

Abstract

Acetaldehyde is a main factor of alcohol-induced asthma. We previously reported that the cysteinyl leukotriene (cys-LT) receptor antagonist, pranlukast hydrate, inhibits acetaldehyde-induced airway hyperresponsiveness in guinea pigs. The purpose of this study was to evaluate the involvement of cys-LT on bronchial responsiveness to acetaldehyde in asthmatic patients. We investigated the bronchial response to inhalation of acetaldehyde in 10 asthmatic patients, who were treated with placebo or pranlukast hydrate (225.5 mg), a cys-LT receptor antagonist, twice a day for 1 wk using a double-blind, randomized, placebo-controlled, cross-over design. Although a remarkable improvement of acetaldehyde bronchoconstriction was observed in 3 out of 10subjects, PC20-AcCHO values were identical between placebo [12.0 (GSEM,1192) mg/ml] and pranlukast [14.7 (GSEM, 1.245) mg/ml] groups. The changes in bronchial responsiveness to acetaldehyde were similar in the six patients who had never experienced alcohol-induced asthma and the four who had. In conclusion, cys-LTs are not involved in acetaldehyde-induced bronchoconstriction. (C) 2001 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:46:34