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Titolo:
Essential fatty acids as possible mediators of the actions of statins
Autore:
Das, UN;
Indirizzi:
EFA Sci LLC, Norwood, MA 02062 USA EFA Sci LLC Norwood MA USA 02062EFA Sci LLC, Norwood, MA 02062 USA
Titolo Testata:
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
fascicolo: 1, volume: 65, anno: 2001,
pagine: 37 - 40
SICI:
0952-3278(200107)65:1<37:EFAAPM>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
HMG-COA REDUCTASE; FREE-RADICAL GENERATION; TUMOR-CELLS INVITRO; LIPID-PEROXIDATION; DIETARY N-3; SIMVASTATIN; INHIBITION; RELEASE; RAT; OMEGA-3-FATTY-ACIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Das, UN EFA Sci LLC, 1420 Providence Highway,Suite 266, Norwood, MA 02062 USA EFA Sci LLC 1420 Providence Highway,Suite 266 Norwood MA USA 02062
Citazione:
U.N. Das, "Essential fatty acids as possible mediators of the actions of statins", PROS LEUK E, 65(1), 2001, pp. 37-40

Abstract

Statins and polyunsaturated fatty acids have similar actions: both enhanceendothelial nitric oxide synthesis, inhibit the production of pro-inflammatory cytokines, lower cholesterol levels, prevent atherosclerosis and are of benefit in coronary heart disease, stroke and osteoporosis. Statins enhance the conversion of linoleic acid and eicosapentaenoic acid to their long chain derivatives. Animals with essential fatty acid deficiency show an increase in HMG-CoA reductase activity, which reverts to normalcy following topical application of linoleic acid. Similarly to statins, polyunsaturated fatty acids also inhibit HMG-CoA reductase activity. In view of the similarity in their actions and as statins influence essential fatty acid metabolism, it is suggested that essential fatty acids and their metabolites may serve as second messengers of the actions of statins. (C) 2001 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 19:41:50