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Titolo:
Plasma fatty acid levels in autistic children
Autore:
Vancassel, S; Durand, G; Barthelemy, C; Lejeune, B; Martineau, J; Guilloteau, D; Andres, C; Chalon, S;
Indirizzi:
INRA, Lab Nutr & Secur Alimentaire, F-78352 Jouy En Josas, France INRA Jouy En Josas France F-78352 entaire, F-78352 Jouy En Josas, France CHU Bretonneau, INSERM, U316, Serv Pedopsychiat, F-37044 Tours, France CHUBretonneau Tours France F-37044 Pedopsychiat, F-37044 Tours, France Fac Pharm, INSERM, U316, Lab Biophys Med & Pharmaceut, Tours, France Fac Pharm Tours France 316, Lab Biophys Med & Pharmaceut, Tours, France Lab Biochim & Biol Mol, Tours, France Lab Biochim & Biol Mol Tours France b Biochim & Biol Mol, Tours, France Fac Med, Tours, France Fac Med Tours FranceFac Med, Tours, France
Titolo Testata:
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
fascicolo: 1, volume: 65, anno: 2001,
pagine: 1 - 7
SICI:
0952-3278(200107)65:1<1:PFALIA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEFICIT-HYPERACTIVITY DISORDER; BLOOD-CELL MEMBRANES; SCHIZOPHRENIC-PATIENTS; PHOSPHOLIPASE-A2 ACTIVITY; PSYCHIATRIC-DISORDERS; SEROTONIN TRANSPORTER; CHOLESTERYL ESTERS; DEPRESSED-PATIENTS; RETT-SYNDROME; METABOLISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Vancassel, S INRA, Lab Nutr & Secur Alimentaire, F-78352 Jouy En Josas, France INRA Jouy En Josas France F-78352 352 Jouy En Josas, France
Citazione:
S. Vancassel et al., "Plasma fatty acid levels in autistic children", PROS LEUK E, 65(1), 2001, pp. 1-7

Abstract

Phospholipid fatty acids are major structural components of neuronal cell membranes, which modulate membrane fluidity and hence function. Evidence from clinical and biochemical sources have indicated changes in the metabolism of fatty acids in several psychiatric disorders. We examined the phospholipid fatty acids in the plasma of a population of autistic subjects compared to mentally retarded controls. Our results showed a marked reduction in the levels of 22: 6n-3 (23%) in the autistic subjects, resulting in significantly lower levels of total (n-3) polyunsaturated fatty acids (PUFA) (20%),without significant reduction in the (n-6) PUFA series, and consequently asignificant increase in the (n-6)/(n-3) ratio (25%). These variations are discussed in terms of potential differences in PUFA dietary intake, metabolism, or incorporation into cellular membranes between the two groups of subjects. These results open up interesting perspectives for the investigationof new biological indices in autism. Moreover, this might have new therapeutic implications in terms of child nutrition. (C) 2001 Harcourt PublishersLtd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/12/19 alle ore 11:09:43