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Titolo:
Arousal effect of orexin A depends on activation of hte histmic system
Autore:
Huang, ZL; Qu, WM; Li, WD; Mochizuki, T; Eguchi, N; Watanabe, T; Urade, Y; Hayaishi, O;
Indirizzi:
Osaka Biosci Inst, Dept Mol Behav Biol, Osaka 5650874, Japan Osaka Biosci Inst Osaka Japan 5650874 l Behav Biol, Osaka 5650874, Japan Kyushu Univ, Med Inst Bioregulat, Dept Mol Immunol, Fukuoka 8128582, JapanKyushu Univ Fukuoka Japan 8128582 pt Mol Immunol, Fukuoka 8128582, Japan Osaka Biosci Inst, Japan Sci & Technol Corp, Core Res Evolut Sci & Technol, Osaka 5650874, Japan Osaka Biosci Inst Osaka Japan 5650874 ci & Technol, Osaka 5650874, Japan
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 17, volume: 98, anno: 2001,
pagine: 9965 - 9970
SICI:
0027-8424(20010814)98:17<9965:AEOOAD>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR MESSENGER-RNA; PROSTAGLANDIN D-2; SLEEP REGULATION; RAT-BRAIN; HYPOTHALAMIC NEUROPEPTIDES; HISTAMINERGIC NEURONS; CORTICAL ACTIVATION; CANINE NARCOLEPSY; WAKEFULNESS; MECHANISMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Hayaishi, O Osaka Biosci Inst, Dept Mol Behav Biol, Osaka 5650874, Japan Osaka Biosci Inst Osaka Japan 5650874 , Osaka 5650874, Japan
Citazione:
Z.L. Huang et al., "Arousal effect of orexin A depends on activation of hte histmic system", P NAS US, 98(17), 2001, pp. 9965-9970

Abstract

Orexin neurons are exclusively localized in the lateral hypothalamic area and project their fibers to the entire central nervous system, including the histaminergic tuberomammillary nucleus (TMN). Dysfunction of the orexin system results in the sleep disorder narcolepsy, but the role of orexin in physiological sleep-wake regulation and the mechanisms involved remain to beelucidated. Here we provide several lines of evidence that orexin A induces wakefulness by means of the TMN and histamine H-1 receptor (H1R). Perfusion of orexin A (5 and 25 pmol/min) for 1 hr into the TMN of rats through a microdialysis probe promptly increased wakefulness for 2 hr after starting the perfusion by 2.5-and 4-fold, respectively, concomitant with a reductionin rapid eye movement (REM) and non-REM sleep. Microdialysis studies showed that application of orexin A to the TMN increased histamine release from both the medial preoptic area and the frontal cortex by approximate to2-fold over the baseline for 80 to 160 min in a dose-dependent manner. Furthermore, infusion of orexin A (1.5 pmol/min) for 6 hr into the lateral ventricleof mice produced a significant increase in wakefulness during the 8 hr after starting infusion to the same level as the wakefulness observed during the active period in wild-type mice, but not at all in H1R gene knockout mice. These findings strongly indicate that the arousal effect of orexin A depends on the activation of histaminergic neurotransmission mediated by H1R.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:59:32