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Titolo:
Analysis of the CYP2D6 gene polymorphism and enzyme activity in African-Americans in Southern California
Autore:
Wan, YJY; Poland, RE; Han, G; Konishi, T; Zheng, YP; Berman, N; Lin, KM;
Indirizzi:
Harbor UCLA Med Ctr, Dept Pathol, Torrance, CA 90509 USA Harbor UCLA Med Ctr Torrance CA USA 90509 Pathol, Torrance, CA 90509 USA Harbor UCLA Med Ctr, Dept Psychiat, Torrance, CA 90509 USA Harbor UCLA MedCtr Torrance CA USA 90509 sychiat, Torrance, CA 90509 USA Cedars Sinai Med Ctr, Dept Psychiat, Los Angeles, CA 90048 USA Cedars Sinai Med Ctr Los Angeles CA USA 90048 , Los Angeles, CA 90048 USA
Titolo Testata:
PHARMACOGENETICS
fascicolo: 6, volume: 11, anno: 2001,
pagine: 489 - 499
SICI:
0960-314X(200108)11:6<489:AOTCGP>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOCHROME-P450 2D6 POLYMORPHISM; DEBRISOQUINE SPARTEINE-TYPE; DRUG-METABOLIZING-ENZYMES; LOWER PREVALENCE; O-DEMETHYLATION; POPULATION; BLACK; DEXTROMETHORPHAN; PHENOTYPE; ALLELES;
Keywords:
CYP2D6; African-American; polymorphism; dextromethorphan;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Lin, KM Harbor UCLA Res & Educ Inst, Res Ctr Psychobiol Ethn, Bldg B-4 S,1124 W Carson St, Torrance, CA 90502 USA Harbor UCLA Res & Educ Inst Bldg B-4 S,1124 W Carson St Torrance CA USA 90502
Citazione:
Y.J.Y. Wan et al., "Analysis of the CYP2D6 gene polymorphism and enzyme activity in African-Americans in Southern California", PHARMACOGEN, 11(6), 2001, pp. 489-499

Abstract

Despite its importance in drug metabolism and disease susceptibility, CYP2D6 activity and genetic polymorphism have rarely been investigated in African-American populations. In order to bridge this gap, we examined the genotype and phenotype of the enzyme in 154 African-American (AA) and 143 Caucasian (C) normal volunteers. AAs are significantly more likely to possess *17and *5, but less likely to have *4. Overall, the two groups were similar in their CYP2D6 activity as measured with dextromethorphan as the probe (metabolic ratio 2.21 +/-0.78 for AAs; 2.11 +/-0.86 for Cs; t = 1.02, NS). Two of four AAs and six of seven Cs were classified as poor metabolizers and have two nonfunctioning alleles. CYP2D6 activity is determined by *17, *4, *5and age in AAs (r(2) = 0.33, f = 18.8, P < 0.001) and by *4 and *XN in Cs (r(2) = 0.14, f = 10.8, P < 0.001). These results support previous findingsdemonstrating the importance of *17 in determining CYP2D6 activity in AAs. Pharmacogenetics 11:489-499 (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 26/01/20 alle ore 00:43:59