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Titolo:
Aspartic protease inhibitors: Expedient synthesis of 2-substituted statines
Autore:
Travins, JM; Bursavich, MG; Veber, DF; Rich, DH;
Indirizzi:
Univ Wisconsin, Dept Chem, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 sin, Dept Chem, Madison, WI 53706 USA Univ Wisconsin, Sch Pharm, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 sin, Sch Pharm, Madison, WI 53706 USA GlaxoSmithKline, King Of Prussia, PA 19406 USA GlaxoSmithKline King Of Prussia PA USA 19406 ing Of Prussia, PA 19406 USA
Titolo Testata:
ORGANIC LETTERS
fascicolo: 17, volume: 3, anno: 2001,
pagine: 2725 - 2728
SICI:
1523-7060(20010823)3:17<2725:APIESO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; AMINO-ACID CONSTITUENT; BETA-KETO-ESTERS; STEREOSELECTIVE SYNTHESIS; RENIN INHIBITORS; PURIFICATION; BLEOMYCIN; PEPSTATIN; SECRETASE; CLEAVAGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Rich, DH Univ Wisconsin, Dept Chem, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 Chem, Madison, WI 53706 USA
Citazione:
J.M. Travins et al., "Aspartic protease inhibitors: Expedient synthesis of 2-substituted statines", ORG LETT, 3(17), 2001, pp. 2725-2728

Abstract

[GRAPHICS]General stereocontrolled synthesis of all four (2,3)-stereoisomers of 2-substituted statines is described. The 2,3-syn and 2,3-anti isomers were synthesized via beta -ketoester reduction and aldol reactions, respectively. Peptides containing 2-substituted statines inhibit porcine pepsin with nanomolar IC50 values.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:00:58