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Titolo:
Parkinsonism and occupational exposure to pesticides
Autore:
Engel, LS; Checkoway, H; Keifer, MC; Seixas, NS; Longstreth, WT; Scott, KC; Hudnell, K; Anger, WK; Camicioli, R;
Indirizzi:
Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Epidemiol, Seattle, WA 98195 USA Oregon Hlth Sci Univ, Pacific NW Agr Safety & Hlth Ctr, Portland, OR 97201USA Oregon Hlth Sci Univ Portland OR USA 97201 lth Ctr, Portland, OR 97201USA Oregon Hlth Sci Univ, Dept Environm Hlth, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 m Hlth, Portland, OR 97201 USA Oregon Hlth Sci Univ, Dept Neurol, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 Neurol, Portland, OR 97201 USA Oregon Hlth Sci Univ, Dept Med, Occupat Med Program, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 rogram, Portland, OR 97201 USA Oregon Hlth Sci Univ, Dept Environm Hlth, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 m Hlth, Portland, OR 97201 USA Oregon Hlth Sci Univ, Ctr Res Occupat & Environm Toxicol, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 oxicol, Portland, OR 97201 USA US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA US EPA Res Triangle Pk NC USA 27711 es Lab, Res Triangle Pk, NC 27711 USA Natl Hlth & Environm Effects Res Lab, Dept Neurol, Res Triangle Pk, NC 27711 USA Natl Hlth & Environm Effects Res Lab Res Triangle Pk NC USA 27711 711 USA
Titolo Testata:
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
fascicolo: 9, volume: 58, anno: 2001,
pagine: 582 - 589
SICI:
1351-0711(200109)58:9<582:PAOETP>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENVIRONMENTAL RISK-FACTORS; YOUNG-ONSET; DISEASE; PREVALENCE; SIGNS; INTOXICATION; EPIDEMIOLOGY; POPULATION; ISRAEL; REGION;
Keywords:
farmer; parkinsonism; pesticides;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Engel, LS NCI, Occupat Epidemiol Branch, 6120 Execut Blvd,EPS 8113,MSC 7240, Bethesda, MD 20892 USA NCI 6120 Execut Blvd,EPS 8113,MSC 7240 Bethesda MD USA 20892 USA
Citazione:
L.S. Engel et al., "Parkinsonism and occupational exposure to pesticides", OCC ENVIR M, 58(9), 2001, pp. 582-589

Abstract

Objective-To examine the risk of parkinsonism related to lifetime occupational exposure to pesticides among a cohort of men, mostly orchardists, in Washington State. Methods-All 310 subjects in this study had previously participated in a cohort study of men occupationally exposed to pesticides. Subjects were givena structured neurological examination and completed a self administered questionnaire which elicited detailed information on pesticide (insecticide, herbicide, and fungicide) use throughout their working careers. Demographiccharacteristics were also sought. Subjects had a mean age of 69.6 years (range 49-96, SD 8.1). There were 238 (76.8%) subjects who reported some occupational exposure to pesticides, whereas 72 (23.2%) reported none. Parkinsonism was defined by the presence of two or more of rest tremor, rigidity, bradykinesia, and impairment of postural reflexes in subjects not on antiparkinsonian medication, or the presence of at least one sign if they were on such medication. Parkinson's disease was not studied explicitly because of the difficulty in distinguishing it from other parkinsonian syndromes. A generalised linear model was used to estimate prevalence ratios (PRs) for parkinsonism relative to history of farming, pesticide use, and use of well water. Results-A PR of 2.0 (95% confidence interval (95% CI) 1.0 to 4.2) was found for subjects in the highest tertile of years of exposure to pesticides; asimilarly increased, non-significant, PR was found for the middle tertile (1.9 (95% CI 0.9 to 4.0)), although a trend test did not show a significantexposure-response relation. No increased risks were found associated with specific pesticides or pesticide classes, nor with a history of farming or use of well water. Conclusion-Parkinsonism may be associated with long term occupational exposure to pesticides, although no associations with specific pesticides couldbe detected. This finding is consistent with most of the publications on this topic.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/06/19 alle ore 17:26:14