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Titolo:
Quantification of limited augmentation of myocardial Tc-99m-tetrofosmin uptake at exercise in stable coronary artery disease
Autore:
Sasao, H; Nakata, T; Hashimoto, A; Wakabayashi, T; Takahashi, T; Miyamoto, K; Tsuchihashi, K; Shimamoto, K;
Indirizzi:
Sapporo Med Univ, Sch Med, Dept Internal Med Cardiol 2, Sapporo, Hokkaido 0600061, Japan Sapporo Med Univ Sapporo Hokkaido Japan 0600061 , Hokkaido 0600061, Japan
Titolo Testata:
NUCLEAR MEDICINE COMMUNICATIONS
fascicolo: 9, volume: 22, anno: 2001,
pagine: 955 - 962
SICI:
0143-3636(200109)22:9<955:QOLAOM>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLOW RESERVE; TC-99M TETROFOSMIN; FAMILIAL HYPERCHOLESTEROLEMIA; YOUNG MEN; TECHNETIUM-99M-TETROFOSMIN; PERFUSION; TL-201; MULTICENTER; ANGIOGRAPHY; TOMOGRAPHY;
Keywords:
Tc-99m-tetrofosmin; mycardial perfusion imaging; exercise stress; coronary artery disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Nakata, T Sapporo Med Univ, Sch Med, Dept Internal Med 2, Chuo Ku, S-1,W-16, Sapporo, Hokkaido 0600061, Japan Sapporo Med Univ S-1,W-16 Sapporo Hokkaido Japan 0600061 , Japan
Citazione:
H. Sasao et al., "Quantification of limited augmentation of myocardial Tc-99m-tetrofosmin uptake at exercise in stable coronary artery disease", NUCL MED C, 22(9), 2001, pp. 955-962

Abstract

We evaluated the diagnostic accuracy of a new method for quantitative analysis of myocardial perfusion at exercise using Tc-99m-tetrofosmin tomographic imaging. Tc-99m-tetrofosmin imaging of an exercise-rest sequence was performed in 30 patients with coronary artery disease (CAD) and eight age-matched control subjects. The exercise-induced myocardial count increase was calculated as the relative value (per cent increase ratio, %IR) to that at rest by correcting for physical decay for Tc-99m and injected doses and by a subtraction technique. Exercise and rest Tc-99m-tetrofosmin images were assessed visually and quantitatively using the per cent peak count and %IR of the myocardial count at exercise. Segments with significant coronary stenosis (diameter stenosis = 75% or more) showed a significantly lower %IR than did those without significant coronary stenosis in the CAD patients (37 +/-19% vs 63 +/- 21%, P<0.05). The diagnostic efficacy of visual analysis fordetecting coronary stenosis was as follows: sensitivity, 58.1% and specificity, 81.4%. When %IR=37% was used for detecting significant coronary stenosis, sensitivity and specificity increased to 74.2% and 93.2%, respectively. Furthermore, the quantitative analysis significantly (P=0.04) improved the overall diagnostic accuracy from 73.3% to 86.7% compared to that of visual assessment. Thus, augmentation of myocardial Tc-99m-tetrofosmin uptake atexercise is blunted in the myocardium with significant coronary stenosis. The calculation of myocardial count increase at exercise relative to that at rest can improve the diagnostic value of Tc-99m-tetrofosmin SPECT imagingand may contribute to more accurate quantification of myocardial ischaemiaand impaired tracer uptake in coronary artery disease. ((C) 2001 Lippincott Williams & Wilkins).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 05:53:17