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Titolo:
Purification and stabilization of Tc-99m-d,1-HMPAO: Role of organic extractants
Autore:
Chattopadhyay, S; Das, MK; Vanaja, R; Ramamoorthy, N;
Indirizzi:
Board Radiat & Isotope Technol, Ctr Variable Energy Cyclotron, Radiopharmaceut Lab, Calcutta 700064, W Bengal, India Board Radiat & Isotope Technol Calcutta W Bengal India 700064 ngal, India Board Radiat & Isotope Technol, Radiopharmaceut Programme, Navi Mumbai 400705, India Board Radiat & Isotope Technol Navi Mumbai India 400705 ai 400705, India
Titolo Testata:
NUCLEAR MEDICINE AND BIOLOGY
fascicolo: 6, volume: 28, anno: 2001,
pagine: 741 - 744
SICI:
0969-8051(200108)28:6<741:PASOTR>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
TC-99M HMPAO; BLOOD;
Keywords:
Tc-99m-d-1-HMPAO; SPECT agent; shelf-life; stabilization; storage; chloroform;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Das, MK Board Radiat & Isotope Technol, Ctr Variable Energy Cyclotron, Radiopharmaceut Lab, 1-AF Bidhan Nagar, Calcutta 700064, W Bengal, India BoardRadiat & Isotope Technol 1-AF Bidhan Nagar Calcutta W Bengal India 700064
Citazione:
S. Chattopadhyay et al., "Purification and stabilization of Tc-99m-d,1-HMPAO: Role of organic extractants", NUCL MED BI, 28(6), 2001, pp. 741-744

Abstract

Tc-99m-d,l-HMPAO, an important SPECT agent for imaging cerebral perfusion,suffers from the disadvantage of an inherent instability and its shelf life has been reported to be 30 min. The latter is a harsh constraint and not compatible with Centralized Radiopharmacy procedures. During the attempts to improve upon the stability of Tc-99m-d,l-HMPAO, preservation of product as an organic extract into suitable solvents like diethylether, ethylacetate, methylethylketone, chloroform was tried out. Chloroform extraction (yield: >90%) resulted in a product having stability not less than 5 hours. Gentle drying of the chloroform extract and reconstitution in normal saline resulted in quantitative recovery of Tc-99m-d,l-HMPAO with acceptable radiochemical purity (>90%). This finding is thus of much significance, especially in the context of centralized large hospital radiopharmacy setting, by rendering convenience and flexibility in scheduling patients. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 22:52:15