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Titolo:
Clinical correlative evaluation of an iterative method for reconstruction of brain SPECT images
Autore:
Nobili, F; Vitali, P; Calvini, P; Bollati, F; Girtler, N; Delmonte, M; Mariani, G; Rodriguez, G;
Indirizzi:
Univ Genoa, Dept Internal Med, Serv Clin Neurophysiol, I-16132 Genoa, Italy Univ Genoa Genoa Italy I-16132 v Clin Neurophysiol, I-16132 Genoa, Italy Univ Genoa, Dept Phys, INFM, Genoa, Italy Univ Genoa Genoa ItalyUniv Genoa, Dept Phys, INFM, Genoa, Italy Univ Genoa, Dept Internal Med, Nucl Med Serv, I-16126 Genoa, Italy Univ Genoa Genoa Italy I-16126 Med, Nucl Med Serv, I-16126 Genoa, Italy
Titolo Testata:
NUCLEAR MEDICINE AND BIOLOGY
fascicolo: 6, volume: 28, anno: 2001,
pagine: 627 - 632
SICI:
0969-8051(200108)28:6<627:CCEOAI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; MODERATE ALZHEIMERS-DISEASE; QUANTITATIVE EEG-ANALYSIS; COMPUTED-TOMOGRAPHY; SYSTEM RESPONSE; PERFUSION; ONSET; DEMENTIA; SEVERITY; AGE;
Keywords:
brain SPECT; selective reminding lest; conjugate gradients; hippocampus; memory;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Nobili, F Univ Genoa, Dept Internal Med, Serv Clin Neurophysiol, Viale Benedetto 15,6, I-16132 Genoa, Italy Univ Genoa Viale Benedetto 15,6 Genoa Italy I-16132 enoa, Italy
Citazione:
F. Nobili et al., "Clinical correlative evaluation of an iterative method for reconstruction of brain SPECT images", NUCL MED BI, 28(6), 2001, pp. 627-632

Abstract

Background: Brain SPECT and PET investigations have showed discrepancies in Alzheimer's disease (AD) when considering data deriving from deeply located structures, such as the mesial temporal lobe, These discrepancies could be due to a variety of factors, including substantial differences in gamma-cameras and underlying technology. Mesial temporal structures are deeply located within the brain and the commonly used Filtered Back-Projection (FBP)technique does not fully take into account either the physical parameters of gamma-cameras or geometry of collimators. In order to overcome these limitations, alternative reconstruction methods have been proposed, such as the iterative method of the Conjugate Gradients with modified matrix (CG). However, the clinical applications of these methods have so far been only anecdotal. The present study was planned to compare perfusional SPECT data as derived from the conventional FBP method and from the iterative CG method, which takes into account the geometrical and physical characteristics of the gamma-camera, by a correlative approach with neuropsychology. Methods: Correlations were compared between perfusion of the hippocampal region. as achieved by both the FBP and the CG reconstruction methods, and ashort-memory test (Selective Reminding Test, SRT), specifically addressingone of its function. A brain-dedicated camera (CERASPECT) was used for SPECT studies with Tc-99m-hexamethylpropylene-amine-oxime in 23 consecutive patients (mean age: 74.2 +/- 6.5) with mild (Mini-Mental Status Examination score greater than or equal to 15, mean 20.3 +/- 3), probable AD. Counts from a hippocampal region in each hemisphere were referred to the average thalamic counts. Results: Hippocampal per-fusion significantly correlated with the MMSE score with similar statistical significance (p < 0.01) between the two reconstruction methods. Correlation between hippocampal perfusion and the SRT score was better with the CG method (r = 0.50 for both hemispheres, p < 0.01) than with the FBP method (r = 0.37 and 0.43, respectively for the right and left hemisphere, p < 0.05 and p < 0.02). The bootstrap procedure showed that such correlation indexes were statistically different both in the right (p < 0.01) and in the left (p < 0.05) hemisphere. Conclusion: These results are interpreted as a better performance of the CG reconstruction method in correctly detecting counts from hippocampal ROI. By using the same gamma-camera or collimator, alternative methods for brain SPECT reconstruction may improve quality of data and then help SPECT diagnostic accuracy, (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/06/19 alle ore 17:01:15