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Titolo:
Hippocampal and cortical sensory gating in rats: Effects of quinpirole microinjections in nucleus accumbens core and shell
Autore:
De Bruin, NMWJ; Ellenbroek, BA; Van Luijtelaar, ELJM; Cools, AR; Stevens, KE;
Indirizzi:
Univ Nijmegen, Dept Comparat & Physiol Psychol, NICI, NL-6500 HB Nijmegen,Netherlands Univ Nijmegen Nijmegen Netherlands NL-6500 HB 00 HB Nijmegen,Netherlands Univ Nijmegen, Dept Psychoneuropharmacol, NICI, NL-6500 HB Nijmegen, Netherlands Univ Nijmegen Nijmegen Netherlands NL-6500 HB 0 HB Nijmegen, Netherlands
Titolo Testata:
NEUROSCIENCE
fascicolo: 1, volume: 105, anno: 2001,
pagine: 169 - 180
SICI:
0306-4522(2001)105:1<169:HACSGI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUDITORY-EVOKED-POTENTIALS; FREELY MOVING RATS; PREPULSE INHIBITION; NEUROPHYSIOLOGICAL EVIDENCE; TEMPORAL VARIABILITY; DOPAMINE INFUSION; ACOUSTIC STARTLE; ANIMAL-MODEL; SCHIZOPHRENIA; RECEPTOR;
Keywords:
auditory evoked potentials; dopamine; D2 receptors; haloperidol; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: De Bruin, NMWJ Univ Nijmegen, Dept Comparat & Physiol Psychol, NICI, POB 9104, NL-6500 HBNijmegen, Netherlands Univ Nijmegen POB 9104 Nijmegen Netherlands NL-6500 HB nds
Citazione:
N.M.W.J. De Bruin et al., "Hippocampal and cortical sensory gating in rats: Effects of quinpirole microinjections in nucleus accumbens core and shell", NEUROSCIENC, 105(1), 2001, pp. 169-180

Abstract

Sensory processing disturbances, as measured in the P50/sensory gating paradigm, have been linked to aberrant auditory information processing and sensory overload in schizophrenic patients. In this paradigm, the response to the second of paired-click stimuli is attenuated by an inhibitory effect ofthe first stimulus. Sensory gating has been observed in most healthy humansubjects and normal laboratory rats. Because mesolimbic dopamine has been implicated in other filtering disturbances such as prepulse inhibition of the acoustic startle response and given the fact that amphetamine and apomorphine have been shown to disrupt gating, this study was performed to investigate the role of mesolimbic dopamine in sensory gating. The dopamine D2 receptor agonist quinpirole (10 mug/0.5 mul) was injected bilaterally in nucleus accumbens core and shell and effects on cortical and hippocampal sensory gating were investigated. Also, effects of the dopamine D2 receptor antagonist haloperidol (0.1 mg/kg, subcutaneously) as pretreatment were studied. First, quinpirole significantly reduced both the amplitude to the first click and gating as measured in the cortex and in the hippocampus. There was a tendency for the quinpirole effects on hippocampal gating to be more pronounced in rats injected in the shell. Secondly, haloperidol did not antagonize effects of quinpirole on hippocampal parameters, whereas haloperidol pretreatment fully antagonized quinpirole effects on cortical parameters. In conclusion, gating can be significantly reduced when a dopamine agonistis specifically targeted at mesolimbic dopamine D2 receptors. However, an important consideration is that the dopaminergic effects in the present study on gating are predominantly mediated by the effects on the amplitude to the first click. This has also been suggested for systemic amphetamine injections in rats and schizophrenic patients. This casts doubt on whether dopamine receptor activation affects the putative inhibitory process between the first and the second stimulus. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:47:44