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Titolo:
Activation of presynaptic group III metabotropic glutamate receptors depresses spontaneous inhibition in layer V of the rat entorhinal cortex
Autore:
Woodhall, G; Evans, DIP; Jones, RSG;
Indirizzi:
Univ Bristol, Sch Med Sci, Dept Physiol, Bristol BS8 1TD, Avon, England Univ Bristol Bristol Avon England BS8 1TD Bristol BS8 1TD, Avon, England
Titolo Testata:
NEUROSCIENCE
fascicolo: 1, volume: 105, anno: 2001,
pagine: 71 - 78
SICI:
0306-4522(2001)105:1<71:AOPGIM>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID RECEPTORS; IN-VITRO; HIPPOCAMPUS; MODULATION; INVITRO; NEURONS; RELEASE; AUTORECEPTORS; FACILITATION; TRANSMISSION;
Keywords:
metabotropic glutamate receptor; epilepsy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Woodhall, G Univ Bristol, Sch Med Sci, Dept Physiol, Bristol BS8 1TD, Avon, England Univ Bristol Bristol Avon England BS8 1TD 1TD, Avon, England
Citazione:
G. Woodhall et al., "Activation of presynaptic group III metabotropic glutamate receptors depresses spontaneous inhibition in layer V of the rat entorhinal cortex", NEUROSCIENC, 105(1), 2001, pp. 71-78

Abstract

Whole cell voltage clamp recording was used to investigate neurotransmitter release onto neurones in deep and superficial layers of rat entorhinal cortex in vitro. Activation of metabotropic glutamate receptors with the agonist (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid depressed spontaneous release of the inhibitory neuro transmitter GABA in layer V, but notin layer II. Depression of transmitter release did not persist in the presence of the sodium channel blocker tetrodotoxin. It seems likely that activation of presynaptic glutamate heteroreceptors inhibits action potential dependent release of neurotransmitter via a direct action at the presynaptic terminal. We confirmed that depression of inhibitory neuro transmission in layer V was mediated by group III metabotropic glutamate receptors using a specific group III antagonist, (RS)-cyclopropyl-4-phosphonophenylglycine. Application of the antagonist alone did not alter the frequency of spontaneous neurotransmitter release, suggesting that the metabotropic glutamate receptor is not tonically active. In layer V of the entorhinal cortex, activation of presynaptic metabotropic glutamate receptors enhances spontaneous glutamate release, and inhibits spontaneous release of GABA. These effects may combine to increase random action potential firing in this layer, thereby reducing its capacity for synchrony generation. Our results are consistent with an anticonvulsant actionfor group III metabotropic, glutamate receptors in the entorhinal cortex. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 22:55:43