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Titolo:
Adenosine preferentially suppresses serotonin(2a) receptor-enhanced excitatory postsynaptic currents in layer V neurons of the rat medial prefrontal cortex
Autore:
Stutzmann, GE; Marek, GJ; Aghajanian, GK;
Indirizzi:
Yale Univ, Sch Med, Ribicoff Basic Res Lab, Dept Psychiat, New Haven, CT 06508 USA Yale Univ New Haven CT USA 06508 , Dept Psychiat, New Haven, CT 06508 USA Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06508 USA Yale Univ NewHaven CT USA 06508 Dept Pharmacol, New Haven, CT 06508 USA Connecticut Mental Hlth Ctr, New Haven, CT 06508 USA Connecticut Mental Hlth Ctr New Haven CT USA 06508 ew Haven, CT 06508 USA
Titolo Testata:
NEUROSCIENCE
fascicolo: 1, volume: 105, anno: 2001,
pagine: 55 - 69
SICI:
0306-4522(2001)105:1<55:APSSRE>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOTROPIC GLUTAMATE RECEPTORS; ATYPICAL ANTIPSYCHOTIC-DRUGS; SYNAPTIC TRANSMISSION; PYRAMIDAL CELLS; EXTRACELLULAR ADENOSINE; ADENINE-NUCLEOTIDES; CEREBRAL-CORTEX; IN-VITRO; TRANSMITTER RELEASE; HIPPOCAMPAL SLICES;
Keywords:
electrophysiology; hallucinogens; 5-hydroxytryptamine(2A) receptors; schizophrenia; late excitatory postsynaptic currents;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Aghajanian, GK Yale Univ, Sch Med, Ribicoff Basic Res Lab, Dept Psychiat, 34 Pk St, New Haven, CT 06508 USA Yale Univ 34 Pk St New Haven CT USA 06508ven, CT 06508 USA
Citazione:
G.E. Stutzmann et al., "Adenosine preferentially suppresses serotonin(2a) receptor-enhanced excitatory postsynaptic currents in layer V neurons of the rat medial prefrontal cortex", NEUROSCIENC, 105(1), 2001, pp. 55-69

Abstract

Serotonin induces 'spontaneous' (non-electrically evoked) excitatory postsynaptic currents in layer V pyramidal neurons in the prefrontal cortex. This is likely due to a serotonin(2A) receptor-mediated focal release of glutamate onto apical dendrites. In addition, activation of the serotonin(2A) receptor selectively enhances late components of electrically evoked excitatory postsynaptic currents. In this study, using in vitro intracellular and whole-cell recording in rat brain slices, we examined the role of adenosine in modulating scrotonin(2A)-enhanced 'spontaneous' and electrically evoked excitatory postsynaptic, currents in layer V pyramidal neurons in the medial prefrontal cortex. Adenosine and N-6-cyclo-pentyladenosine, an A, adenosine agonist, markedly suppressed the serotonin(2A)-induced ('spontaneous') excitatory postsynaptic currents. However, adenosine had no effect on spontaneous miniature (tetrodotoxin-insensitive) postsynaptic potentials. Adenosine also blocked the late excitatory postsynaptic currents induced by the serotonin(2A/2C) agonist R(-)-2,5-dimethoxy-4-iodoamphetamine hydrochloride. Surprisingly, in contrast to other regions, adenosine had a relatively small effect on electrically evoked fast excitatory postsynaptic currents. These findings represent a novel demonstration of adenosine's ability to preferentially modulate serotonin(2A)-mediated synaptic events in the medialprefrontal cortex. As the serotonin2A receptor is closely linked with the effects of atypical antipsychotics and hallucinogens, further understandingof the modulators of this receptor such as adenosine may provide useful therapeutic applications. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

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Documento generato il 07/08/20 alle ore 00:45:03