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Titolo:
Dynamic induction of the long pentraxin PTX3 in the CNS after limbic seizures: Evidence for a protective role in seizure-induced neurodegeneration
Autore:
Ravizza, T; Moneta, D; Bottazzi, B; Peri, G; Garlanda, C; Hirsch, E; Richards, GJ; Mantovani, A; Vezzani, A;
Indirizzi:
Mario Negri Inst Pharmacol Res, Dept Neurosci, Dept Expt Neurol, I-20157 Milan, Italy Mario Negri Inst Pharmacol Res Milan Italy I-20157 I-20157 Milan, Italy Mario Negri Inst Pharmacol Res, Dept Immunol & Cell Biol, I-20157 Milan, Italy Mario Negri Inst Pharmacol Res Milan Italy I-20157 I-20157 Milan, Italy Univ Turin, Dept Genet Biol & Biochem, I-10124 Turin, Italy Univ Turin Turin Italy I-10124 enet Biol & Biochem, I-10124 Turin, Italy F Hoffmann La Roche & Co Ltd, Preclin Res, CNS, CH-4070 Basel, SwitzerlandF Hoffmann La Roche & Co Ltd Basel Switzerland CH-4070 asel, Switzerland Univ Milan, Ist Patol Gen, I-20122 Milan, Italy Univ Milan Milan Italy I-20122 ilan, Ist Patol Gen, I-20122 Milan, Italy
Titolo Testata:
NEUROSCIENCE
fascicolo: 1, volume: 105, anno: 2001,
pagine: 43 - 53
SICI:
0306-4522(2001)105:1<43:DIOTLP>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID-P COMPONENT; C-REACTIVE PROTEIN; ACUTE-PHASE PROTEINS; NEURONAL PENTRAXIN; INDUCIBLE EXPRESSION; RECEPTOR ANTAGONIST; STATUS EPILEPTICUS; RAT HIPPOCAMPUS; PENTAXIN FAMILY; MEMBER;
Keywords:
acute phase proteins; cytokines; epilepsy; kainic acid; limbic system; pentraxins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Vezzani, A Mario Negri Inst Pharmacol Res, Dept Neurosci, Dept Expt Neurol, Via Eritrea 62, I-20157 Milan, Italy Mario Negri Inst Pharmacol Res Via Eritrea 62 Milan Italy I-20157
Citazione:
T. Ravizza et al., "Dynamic induction of the long pentraxin PTX3 in the CNS after limbic seizures: Evidence for a protective role in seizure-induced neurodegeneration", NEUROSCIENC, 105(1), 2001, pp. 43-53

Abstract

Pentraxin 3, a prototypic long pentraxin, is induced by proinflammatory signals in the brain. Inflammatory cytokines are rapidly induced in glia by epileptic activity. We show that pentraxin 3 immunoreactivity and mRNA are enhanced in the rat forebrain above undetectable control levels by limbic seizures with a dual pattern of induction. Within 6 h from seizure onset, pentraxin 3 immunoreactivity was increased in astrocytes. Eighteen to 48 It later, specific neuronal populations and leucocytes were strongly immunoreactive only in areas of neurodegeneration. This staining was abolished when neuronal cell loss, but not seizures, was prevented by blocking N-methyl-D-aspartate receptors. Pentraxin 3 -/- mice had a more widespread seizure-related neuronal damage in the forebrain than their wild-type littermates although both groups had similar epileptic activity. Our results provide evidence that pentraxin 3 is synthesized in brain after seizures and may exert a protective role in seizure-induced neurodegeneration. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

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Documento generato il 22/01/20 alle ore 06:48:07