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Titolo:
Immunohistochemical localization of group I and II metabotropic glutamate receptors in control and amyotrophic lateral sclerosis human spinal cord: Upregulation in reactive astrocytes
Autore:
Aronica, E; Catania, MV; Geurts, J; Yankaya, B; Troost, D;
Indirizzi:
Univ Amsterdam, Acad Med Ctr, Dept Neuropathol, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands CNR, Inst Bioimaging & Pathophysiol Cent Nervous Syst, Catania, Italy CNRCatania Italy ging & Pathophysiol Cent Nervous Syst, Catania, Italy
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 105, anno: 2001,
pagine: 509 - 520
SICI:
0306-4522(2001)105:2<509:ILOGIA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; DISMUTASE TRANSGENIC MICE; CALCIUM-BINDING PROTEINS; SUPEROXIDE-DISMUTASE; DORSAL HORN; CORTICAL ASTROCYTES; MOTOR-NEURONS; UP-REGULATION; WHITE-MATTER; RAT;
Keywords:
metabotropic glutamate receptors; spinal cord; amyotrophic lateral sclerosis; glia; calcium-binding proteins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Aronica, E Univ Amsterdam, Acad Med Ctr, Dept Neuropathol, Meibergdreef 9,NL-1105 AZAmsterdam, Netherlands Univ Amsterdam Meibergdreef 9 Amsterdam Netherlands NL-1105 AZ
Citazione:
E. Aronica et al., "Immunohistochemical localization of group I and II metabotropic glutamate receptors in control and amyotrophic lateral sclerosis human spinal cord: Upregulation in reactive astrocytes", NEUROSCIENC, 105(2), 2001, pp. 509-520

Abstract

Excitotoxicity, which is mediated by the excessive activation of glutamatereceptors, has been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). There is substantial information about the distribution and function of ionotropic glutamate receptors in the spinal cord, although the role of metabotropic glutamate receptors (mGluRs) is poorly understood in this region of the brain, particularly under pathological conditions. We used immunocytochemistry to study the general distribution of group I and group II mGluR immunoreactivity in the human spinal cord, as well as the cell-specific expression of these receptors. We also investigated whether mGluR expression was altered in the spinal cord of patients with sporadic and familial ALS. Immunocytochemical analysis of control human spinal cord demonstrated that mGluR1 alpha and mGluR5 (group I mGluRs) were highly represented in neuronal cells throughout the spinal cord. mGluR I a showed the highest relative level of expression in ventral horn neurons (laminae VIII and IX), whereas intense mGluR5 immunoreactivity was observed within the dorsal horn (superficial laminae I and 11). Group 11 mGluRs (mGluR2/3) immunoreactivity was mainly concentrated in the inner part of the lamina Il. With respect to specific neuronal populations, mGluR2/3 and mGluR5 appeared to be most frequently expressed in calbindin-containing and calretinin-containing cells, respectively. In control spinal cord only sparse astrocytes showed a weak to moderate mGluR immunoreactivity. Regional differences in immunoreactivity were apparent in ALS compared to control. In particular, mGluR expression was increased in reactive glial cells in both gray (ventral horn) andwhite matter of ALS spinal cord. Upregulation of mGluRs in reactive astrocytes may represent a critical mechanism for modulation of glial function and changes in glial-neuronal communication in the course of neurodegenerative diseases. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 08:53:16