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Titolo:
Orphanin-FQ/nociceptin inhibits kindling epileptogenesis and enhances hippocampal feed-forward inhibition
Autore:
Gutierrez, R; Leff, P; Romo-Parra, H; Acevedo, R; Anton, B;
Indirizzi:
Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Dept Fisiol, Mexico City 07000, DF, Mexico Inst Politecn Nacl Mexico City DF Mexico 07000 ico City 07000, DF, Mexico Inst Nacl Psiquiatria, Div Invest Clin, Mexico City, DF, Mexico Inst Nacl Psiquiatria Mexico City DF Mexico lin, Mexico City, DF, Mexico
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 105, anno: 2001,
pagine: 325 - 333
SICI:
0306-4522(2001)105:2<325:OIKEAE>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; LONG-TERM POTENTIATION; NOCICEPTIN/ORPHANIN FQ; POTASSIUM CONDUCTANCE; SYNAPTIC TRANSMISSION; TISSUE DISTRIBUTION; RAT HIPPOCAMPUS; OPIOID RECEPTOR; MESSENGER-RNA; LOCALIZATION;
Keywords:
orphanin-FQ/nociceptin; kindling; epilepsy; feed-forward inhibition; limbic system; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Gutierrez, R Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Dept Fisiol, ApartadoPostal 14-740, Mexico City 07000, DF, Mexico Inst Politecn Nacl Apartado Postal 14-740 Mexico City DF Mexico 07000
Citazione:
R. Gutierrez et al., "Orphanin-FQ/nociceptin inhibits kindling epileptogenesis and enhances hippocampal feed-forward inhibition", NEUROSCIENC, 105(2), 2001, pp. 325-333

Abstract

The role of Orphanin-FQ/nociceptin in synaptic plasticity was assessed by its potency in modulating kindling epileptogenesis in vivo, and feed-forward inhibition in hippocampal recordings in vitro. In addition, a specific rabbit antiserum against this peptide was obtained and the immunohistochemical distribution of nociceptin was determined in rat brain slices. After the establishment of kindling epilepsy, by daily electrical stimulation of the piriform cortex, the i.c.v. injection of nociceptin, 20 min before the kindling stimulation, was not able to block the generation of the generalized seizures, nor to alter their duration. However, the i.c.v. injection of nociceptin, 20 min before each stimulation along the kindling process, depressed its development in a dose-dependent manner. This effect was specific since the nociceptin antagonist [Phe1psi(CH2-NH)Gly2]NC(1-13)NH2, but not the broad-spectrum opiate antagonist, naloxone, was able to completely block nociceptin actions. The inhibitory role of nociceptin was assessed by in vitrorecordings from entorhinal cortex-hippocampal slices. By single pulses applied over the Schaffer collaterals, we found that synaptic transmission wasfacilitated onto CA1, but using a paired-pulse protocol, xe found that nociceptin potentiated feedforward inhibition. The immunohistochemical data show that nociceptin is expressed in limbic cortical regions, including the piriform cortex and the hippocampus. Our results demonstrate that nociceptin exerts a modulatory role in limbicexcitability and Suggest that it provides an inhibitory control in the development of epilepsy by possibly inhibiting the spread of excitation through the system, by favoring feed-forward inhibition. (C) 2001 IBRO. Publishedby Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:34:26