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Titolo:
Strain differences in freezing behavior of PVG hooded and Sprague-Dawley rats: differential cortical expression of cholecystokinin(2) receptors
Autore:
Farook, JM; Zhu, YZ; Wang, H; Moochhala, S; Lee, L; Wong, PTH;
Indirizzi:
Natl Univ Singapore, Fac Med, Dept Pharmacol, Singapore 117597, Singapore Natl Univ Singapore Singapore Singapore 117597 ngapore 117597, Singapore Def Med Res Inst, Combat Care & Performance Lab, Singapore 119260, Singapore Def Med Res Inst Singapore Singapore 119260 Singapore 119260, Singapore
Titolo Testata:
NEUROREPORT
fascicolo: 12, volume: 12, anno: 2001,
pagine: 2717 - 2720
SICI:
0959-4965(20010828)12:12<2717:SDIFBO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANXIETY;
Keywords:
cholecystokinin (CCK)(2) receptor expression; cholecystokinin tetrapeptide; fear and anxiety; freezing behavior; LY225910; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Wong, PTH Natl Univ Singapore, Fac Med, Dept Pharmacol, 18 Med Dr,Kent Ridge, Singapore 117597, Singapore Natl Univ Singapore 18 Med Dr,Kent Ridge Singapore Singapore 117597
Citazione:
J.M. Farook et al., "Strain differences in freezing behavior of PVG hooded and Sprague-Dawley rats: differential cortical expression of cholecystokinin(2) receptors", NEUROREPORT, 12(12), 2001, pp. 2717-2720

Abstract

PVG hooded, but not Sprague-Dawley (SD), rats showed remarkable freezing behavior on cat exposure. Experiments using cDNA microarray and reverse transcriptase-polymerase chain reaction (RT-PCR) demonstrated that cholecystokinin (CCK)(2) receptors were expressed to a greater extent in the PVG hoodedrats. A CCK2 antagonist, LY225910, inhibited freezing behavior in the PVG hooded rats while a CCK2 agonist, CCK-4, increased freezing behavior in theSD rats. These results strongly suggest that CCK2 receptors mediate the freezing behavior and the differential expression of these receptors underliethe strain difference in such behavior. NeuroReport 12:2717-2720 (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 08/04/20 alle ore 12:02:11