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Titolo:
Damage to nuclear DNA in Lewy body disease
Autore:
Love, S;
Indirizzi:
Frenchay Hosp, Dept Neuropathol, Inst Clin Neurosci, Bristol BS16 1LE, Avon, England Frenchay Hosp Bristol Avon England BS16 1LE istol BS16 1LE, Avon, England
Titolo Testata:
NEUROREPORT
fascicolo: 12, volume: 12, anno: 2001,
pagine: 2725 - 2729
SICI:
0959-4965(20010828)12:12<2725:DTNDIL>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARKINSONS-DISEASE; SUBSTANTIA-NIGRA; CASPASE ACTIVATION; OXIDATIVE STRESS; REPAIR PROTEINS; CELL-DEATH; L-DOPA; APOPTOSIS; BRAIN; MECHANISMS;
Keywords:
caspase-3; deoxynucleotidyl transferase-mediated dUTP-digoxygenin nick end-labelling (TUNEL); DNA-dependent protein kinase catalytic subunit; DNA damage; DNA repair; L-DOPA; Lewy body disease; Oxidative stress; Parkinson's disease; poly(ADP-ribose) polymerase (PARP);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Love, S Frenchay Hosp, Dept Neuropathol, Inst Clin Neurosci, Bristol BS16 1LE, Avon, England Frenchay Hosp Bristol Avon England BS16 1LE 16 1LE, Avon, England
Citazione:
S. Love, "Damage to nuclear DNA in Lewy body disease", NEUROREPORT, 12(12), 2001, pp. 2725-2729

Abstract

To assess the significance of damaged nuclear DNA in autopsy brain tissue in Lewy body disease (LBD), we examined the patterns of expression of two DNA repair enzymes (PARP and DNA-PKCS), TUNEL and caspase-3 activation, in sections of midbrain and frontal cortex from nine patients with LBD who had not received L-DOPA, and from five neurologically normal controls. In LBD but not controls, many neurons and glia in the midbrain had translocated DNA-PKCS and PARP from the cytoplasm into the nucleus, particularly in the substantia nigra, LBD midbrains contained sparse TUNEL-positive neurons. Caspase-3 activity was largely restricted to microglia but was detected in an occasional nigral neuron. Nuclear DNA damage occurs in vivo in LBD but only rarely indicates neuronal apoptosis. NeuroReport 12:2725-2729 (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 22/01/20 alle ore 12:38:27