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Titolo:
NT-3 regulates BDNF-induced modulation of synaptic transmission in cultured hippocampal neurons
Autore:
Paul, J; Gottmann, K; Lessmann, V;
Indirizzi:
Ruhr Univ Bochum, Dept Cell Physiol, D-44780 Bochum, Germany Ruhr Univ Bochum Bochum Germany D-44780 Physiol, D-44780 Bochum, Germany Ruhr Univ Bochum, Dept Mol Neurobiochem, D-44780 Bochum, Germany Ruhr UnivBochum Bochum Germany D-44780 biochem, D-44780 Bochum, Germany
Titolo Testata:
NEUROREPORT
fascicolo: 12, volume: 12, anno: 2001,
pagine: 2635 - 2639
SICI:
0959-4965(20010828)12:12<2635:NRBMOS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA; RAT; NEUROTROPHINS; RECEPTORS; TRKB; SYNAPTOGENESIS; EXPRESSION; GROWTH; CELLS;
Keywords:
BDNF; c-fos; hippocampal neurons; miniature synaptic currents; neurotrophins; NT-3; synaptic development;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Lessmann, V Ruhr Univ Bochum, Dept Cell Physiol, NC7-132, D-44780 Bochum, Germany Ruhr Univ Bochum NC7-132 Bochum Germany D-44780 chum, Germany
Citazione:
J. Paul et al., "NT-3 regulates BDNF-induced modulation of synaptic transmission in cultured hippocampal neurons", NEUROREPORT, 12(12), 2001, pp. 2635-2639

Abstract

BDNF and NT-3 can modulate the development and plasticity of central synaptic transmission. Although the expression of NT-3 and BDNF in the rodent hippocampus coincides during perinatal development, little is known about possible functional interactions between both neurotrophins in synaptic development. Here, we have investigated the effects of combined longterm application of NT-3 and BDNF on excitatory glutamatergic (mEPSC) and inhibitory GABAergic miniature synaptic currents (mIPSC) in cultured embryonic hippocampal neurons. Our results show that the BDNF-induced twofold increase in mEPSCfrequency is abolished by pre-treatment with NT-3. In addition, the NT-3-induced twofold downregulation of mIPSC frequency is reversed by BDNF. Finally, the BDNF-induced increase in c-fos expression is reduced by 50% after pretreatment with NT-3. In summary, these data suggest an NT-3 controlled modulation of BDNF signalling in differentiating hippocampal neurons. NeuroReport 12:2635-2639 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 22:21:59