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Titolo:
Group I mGluR antagonist AIDA protects nigral DA cells from MPTP-induced injury
Autore:
Aguirre, JA; Andbjer, B; Gonzalez-Baron, S; Hansson, A; Stromberg, I; Agnati, LF; Fuxe, K;
Indirizzi:
Univ Malaga, Sch Med, Dept Physiol, E-29080 Malaga, Spain Univ Malaga Malaga Spain E-29080 ed, Dept Physiol, E-29080 Malaga, Spain Karolinska Inst, Dept Neurosci, Div Cellular & Mol Neurochem, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 chem, S-17177 Stockholm, Sweden Univ Modena, Dept Biomed Sci, I-41100 Modena, Italy Univ Modena Modena Italy I-41100 Dept Biomed Sci, I-41100 Modena, Italy
Titolo Testata:
NEUROREPORT
fascicolo: 12, volume: 12, anno: 2001,
pagine: 2615 - 2617
SICI:
0959-4965(20010828)12:12<2615:GIMAAP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOTROPIC GLUTAMATE RECEPTORS; SUBSTANTIA-NIGRA; NEURONAL DEATH; 1-AMINOINDAN-1,5-DICARBOXYLIC ACID; DOPAMINE NEURONS; RAT; VITRO; NUCLEUS; MONKEYS; NUMBER;
Keywords:
1-aminoindan-1,5-dicarboxylic acid; dopamine; immunocytochemistry; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; mGluR1; mouse; Parkinson's disease; stereology; substantia nigra; tyrosine hydroxylase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Aguirre, JA Univ Malaga, Sch Med, Dept Physiol, E-29080 Malaga, Spain UnivMalaga Malaga Spain E-29080 siol, E-29080 Malaga, Spain
Citazione:
J.A. Aguirre et al., "Group I mGluR antagonist AIDA protects nigral DA cells from MPTP-induced injury", NEUROREPORT, 12(12), 2001, pp. 2615-2617

Abstract

The effects of i.c.v. injection of AIDA, a group I mGluR antagonist, were studied on the nigral DA cells after MPTP-induced injury in the black mouse, using TH immunocytochemistry and unbiased stereology. MPTP reduced the total number of TH-IR neurons by 55.2% and non-TH-IR neurons by 27.5% A 15 min AIDA pre-treatment (10 nmol) selectively counteracted the loss of TH-IR cells caused by MPTP as evaluated 10 days after the insult without changing the total number of nonneuronal cell nuclei. The results suggest that groupI mGluR antagonists may have a neuroprotective role against MPTP-induced degeneration of DA neurons and thus probably also against neurodegenerative processes occurring in Parkinson's disease. NeuroReport 12:2615-2617 (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 25/01/20 alle ore 19:36:10