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Titolo:
Ca2+-dependent activation of tyrosine hydroxylase involves MEK1
Autore:
Griffiths, J; Marley, PD;
Indirizzi:
Univ Melbourne, Dept Pharmacol, Melbourne, Vic 3010, Australia Univ Melbourne Melbourne Vic Australia 3010 elbourne, Vic 3010, Australia
Titolo Testata:
NEUROREPORT
fascicolo: 12, volume: 12, anno: 2001,
pagine: 2679 - 2683
SICI:
0959-4965(20010828)12:12<2679:CAOTHI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADRENAL CHROMAFFIN CELLS; SITE-DIRECTED MUTAGENESIS; PROTEIN-KINASE-C; NICOTINIC RESPONSES; IN-VITRO; PHOSPHORYLATION; SERINE-40; SER(19); SER(31); SER(40);
Keywords:
Ca2+; chromaffin cells; MEK; mitogen activated protein kinase; PD098059; tyrosine hydroxylase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Marley, PD Univ Melbourne, Dept Pharmacol, Melbourne, Vic 3010, Australia Univ Melbourne Melbourne Vic Australia 3010 ic 3010, Australia
Citazione:
J. Griffiths e P.D. Marley, "Ca2+-dependent activation of tyrosine hydroxylase involves MEK1", NEUROREPORT, 12(12), 2001, pp. 2679-2683

Abstract

Tyrosine hydroxylase (TOH) activity is regulated acutely by phosphorylation of serines 8, 19, 31 and 40. The only kinases known to phosphorylate Ser31 are the mitogen-activated protein kinases MAPK-1 and 2. The involvement of these kinases in TOH activation in situ was therefore investigated using intact bovine chromaffin cells. Nicotine, K+ and A23187 increased TOH activity over 10 min in a Ca2+-dependent manner. The response to all three was reduced by PID098059, a selective inhibitor of the upstream activator of MAPK, MEK1. In contrast, TOH activation by forskolin and phorbol dibutyrate were unaffected by PD098059. The results support a key role for MEK1/MAPK in the acute activation of TOH by nicotinic receptors and by other agonists that increase cytosolic Ca2+. NeuroReport 12:2679-2683 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 14:37:56