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Titolo:
Altered dopaminergic transmission in the anorexic anx/anx mouse striatum
Autore:
Johansen, JE; Teixeira, VL; Johansson, C; Serrao, P; Berggren, PO; Soares-Da-Silva, P; Schalling, M; Bertorello, AM;
Indirizzi:
Karolinska Hosp, Karolinska Inst, Dept Mol Med, Neurogenet Unit, S-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-17176 Unit, S-17176 Stockholm, Sweden Univ Porto, Inst Pharmacol & Therapeut, P-4200 Oporto, Portugal Univ Porto Oporto Portugal P-4200 l & Therapeut, P-4200 Oporto, Portugal
Titolo Testata:
NEUROREPORT
fascicolo: 12, volume: 12, anno: 2001,
pagine: 2737 - 2741
SICI:
0959-4965(20010828)12:12<2737:ADTITA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
FEEDING-BEHAVIOR; DEFICIENT MICE; NA,K-ATPASE; BRAIN; MUTATION; NEURONS; SYSTEMS; GENE; RATS;
Keywords:
Na+,K+-ATPase; norepinephrine; tyrosine hydroxylase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Johansen, JE Karolinska Hosp, Karolinska Inst, Dept Mol Med, Neurogenet Unit, L8-00, S-17176 Stockholm, Sweden Karolinska Hosp L8-00 Stockholm Sweden S-17176 kholm, Sweden
Citazione:
J.E. Johansen et al., "Altered dopaminergic transmission in the anorexic anx/anx mouse striatum", NEUROREPORT, 12(12), 2001, pp. 2737-2741

Abstract

We demonstrate abnormal dopaminergic neurotransmission in anorexic mice, homozygous for a recessive mutation (anx) causing starvation and motor disturbances. Isolated neurons from anx/anx striatum displayed a markedly increased activity of the Na+,K+-ATPase compared with normal littermates. Dopamine down-regulates Na+,K+-ATPase activity in striatal medium spiny neurons inrat, mouse and guinea pig. However, addition of dopamine in vitro failed to suppress the increased activity in anx/anx striatal neurons. Striatal dopamine and its metabolites, but not norepinephrine, were slightly but significantly lower in anx/anx mice than in normal littermates. We suggest that abnormal dopaminergic transmission may contribute to the anx phenotype. NeuroReport 12:2737-2741 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 13:04:11