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Titolo:
Effects of age and gender on the expression of brain-derived neurotrophic factor mRNA in rat retrosplenial cortex following administration of dizocilpine
Autore:
Matsuki, H; Shirayama, Y; Hashimoto, K; Tanaka, A; Minabe, Y;
Indirizzi:
Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Div Cort Funct Disorders, Tokyo, Japan Natl Ctr Neurol & Psychiat Tokyo Japan rt Funct Disorders, Tokyo, Japan Tokyo Womens Med Coll, Dept Neuropsychiat, Tokyo 162, Japan Tokyo Womens Med Coll Tokyo Japan 162 pt Neuropsychiat, Tokyo 162, Japan
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 2, volume: 25, anno: 2001,
pagine: 258 - 266
SICI:
0893-133X(200108)25:2<258:EOAAGO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
BDNF MESSENGER-RNA; SHOCK-PROTEIN HSP-70; HEAT-SHOCK; POSTERIOR CINGULATE; CEREBROCORTICAL NEURONS; GENE RESPONSE; FEMALE RATS; RECEPTOR; SCHIZOPHRENIA; PHENCYCLIDINE;
Keywords:
NMDA receptor antagonist; brain-derived neurotrophic factor; heat shock protein; aging; gender; retrosplenial cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Hashimoto, K Welfide Corp, 7-25 Koyata 3 Chome, Iruma, Saitama 3580026, Japan Welfide Corp 7-25 Koyata 3 Chome Iruma Saitama Japan 3580026
Citazione:
H. Matsuki et al., "Effects of age and gender on the expression of brain-derived neurotrophic factor mRNA in rat retrosplenial cortex following administration of dizocilpine", NEUROPSYCH, 25(2), 2001, pp. 258-266

Abstract

Using in situ hybridization, we studied the effects of age and gender on the expression of brain-derived neurotrophic factor (BDNF) mRNA and heat shock protein hsp-70 mRNA in the rat retrosplenial cortex following administration of the noncompetitive NMDA receptor antagonist (+)-MK-801 (dizocilpine). Male and female Sprague-Dawley rats (5 weeks, 12 weeks, or 10 months old) were given a single intraperitoneal injection of saline (1 ml/kg) or dizocilpine (0.3, 1.0, or 3.0 mg/kg). No expression of BDNF mRNA and hsp-70 mRNA was detected in the rat retrosplenial cortex after administration of saline (1 ml/kg, IP). Administration of dizocilpine (0.3, 1.0, or 3.0 mg/kg, IP) caused a marked induction of BDNF mRNA and hsp-70 mRNA in the retrosplenial cortex of male and female rats, in a dose-dependent manner. Female rats were more sensitive to the induction of BDNF mRNA and hsp-70 mRNA in the retrosplenial cortex by dizocilpine as compared to male rats. It was also found that adult (12 weeks old) and aged (10 months old) rats were more sensitive to the induction of hsp-70 mRNA and BDNF mRNA in the retrosplenial cortex by dizocilpine as compared to young (5 weeks old) rats. These results suggest that the age and gender differences observed in the expression of BDNF mRNA and hsp-70 mRNA in the retrosplenial cortex by dizocilpine may be associated with the differences in dizocilpine-induced neurotoxicity observedwith gender and age within the same region. [Neuropsychopharmacology 25:258-266, 2001] (C) 2001 American College of Neuropsychology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:41:40