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Titolo:
Repeated exposure to rewarding brain stimulation downregulates GluR1 expression in the ventral tegmental area
Autore:
Carlezon, WA; Todtenkopf, MS; McPhie, DL; Pimentel, P; Pliakas, AM; Stellar, JR; Trzcinska, M;
Indirizzi:
Harvard Univ, McLean Hosp, Sch Med, Dept Psychiat,MRC 217, Belmont, MA 02178 USA Harvard Univ Belmont MA USA 02178 Psychiat,MRC 217, Belmont, MA 02178 USA Northeastern Univ, Dept Psychol, Boston, MA 02115 USA Northeastern Univ Boston MA USA 02115 Dept Psychol, Boston, MA 02115 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 2, volume: 25, anno: 2001,
pagine: 234 - 241
SICI:
0893-133X(200108)25:2<234:RETRBS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOS-LIKE IMMUNOREACTIVITY; MESSENGER-RNA EXPRESSION; SELF-STIMULATION; BEHAVIORAL SENSITIZATION; AMPHETAMINE; COCAINE; GLUTAMATE; NEURONS; RAT; FOREBRAIN;
Keywords:
brain stimulation reward; lateral hypothalamus; glutamate; AMPA; dopamine; protein; addiction; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Carlezon, WA Harvard Univ, McLean Hosp, Sch Med, Dept Psychiat,MRC 217, 115 Mill St, Belmont, MA 02178 USA Harvard Univ 115 Mill St Belmont MA USA 02178 t, MA 02178 USA
Citazione:
W.A. Carlezon et al., "Repeated exposure to rewarding brain stimulation downregulates GluR1 expression in the ventral tegmental area", NEUROPSYCH, 25(2), 2001, pp. 234-241

Abstract

There is considerable evidence that drug reward and brain stimulation reward (BSR) share common neural substrates. Although it is known that exposureto drugs of abuse causes a variety of molecular changes in brain reward systems, little is known about the molecular consequences of BSR. We report that repeated exposure to rewarding stimulation of the medial forebrain bundle (MFB) selectively decreases expression of GluR1 (an AMPA receptor subunit) in the VTA, without effect on expression of several other proteins (GluR2, NMDAR1, tyrosine hydroxylase). This effect of BSR on GluR1 expression isopposite of that caused by intermittent exposure to cocaine and morphine, which are known to elevate GluR1 expression in the VTA. Considering that elevated GluR1 expression in the VTA has been associated with increased sensitivity to drug reward, the finding that BSR and drugs of abuse have opposite effects on GluR1 expression in this region may provide an explanation forwhy the reward-related effects of many drugs (cocaine, morphine, amphetamine, PCP, nicotine) do not sensitize with repeated testing in BSR proceduresthat quantify reward strength. [Neuropsychopharmacology 25:234-241, 2001] (C) 2001 American College of Neuropsychopharmacology. Published by ElsevierScience Inc.

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Documento generato il 07/04/20 alle ore 04:19:23