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Titolo:
Effect of olanzapine on functional responses from sensitized D-1-dopamine receptors in rats with neonatal dopamine loss
Autore:
Moy, SS; Knapp, DJ; Breese, GR;
Indirizzi:
Univ N Carolina, Sch Med, Skipper Bowles Ctr Alcohol Studies, Ctr Neurosci, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 rosci, Chapel Hill, NC 27599 USA Univ N Carolina, Ctr Neurosci, Dept Psychiat, Chapel Hill, NC USA Univ N Carolina Chapel Hill NC USA i, Dept Psychiat, Chapel Hill, NC USA Univ N Carolina, Ctr Neurosci, Dept Anesthesiol, Chapel Hill, NC USA Univ N Carolina Chapel Hill NC USA Dept Anesthesiol, Chapel Hill, NC USA Univ N Carolina, Ctr Neurosci, Dept Pharmacol, Chapel Hill, NC USA Univ N Carolina Chapel Hill NC USA , Dept Pharmacol, Chapel Hill, NC USA Univ N Carolina, Sch Med, Neurodev Disorders Res Ctr, Chapel Hill, NC USA Univ N Carolina Chapel Hill NC USA isorders Res Ctr, Chapel Hill, NC USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 2, volume: 25, anno: 2001,
pagine: 224 - 233
SICI:
0893-133X(200108)25:2<224:EOOOFR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
LESCH-NYHAN-SYNDROME; 6-HYDROXYDOPAMINE-LESIONED RATS; BEHAVIORAL PHARMACOLOGY; 6-OHDA-LESIONED RATS; ANTIPSYCHOTIC-DRUGS; BRAIN DOPAMINE; FOS EXPRESSION; CLOZAPINE; D-1; HALOPERIDOL;
Keywords:
antipsychotic drugs; D-1-dopamine receptor; Fos; olanzapine; self-injurious behavior; sensitization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Moy, SS Univ N Carolina, Sch Med, Skipper Bowles Ctr Alcohol Studies, Ctr Neurosci, CB 7178, Chapel Hill, NC 27599 USA Univ N Carolina CB 7178 ChapelHill NC USA 27599 ill, NC 27599 USA
Citazione:
S.S. Moy et al., "Effect of olanzapine on functional responses from sensitized D-1-dopamine receptors in rats with neonatal dopamine loss", NEUROPSYCH, 25(2), 2001, pp. 224-233

Abstract

Previous work has suggested that the therapeutic efficacy of olanzapine might be partially dependent on action at the D-1-dopamine (DA) receptor site. Because early DA loss can lead to supersensitive D-1-DA receptors, effects of olanzapine were investigated in adult rats given lesions to DA-containing neurons as neonates. In these animals, locomotor effects of SKF-38393 (a D-1-DA agonist.) were attenuated by olanzapine, but at doses (5 and 10 mg/kg) that decreased activity when given alone. Olanzapine prevented induction of striatal Fos protein by SKF-38393 and partially attenuated the long-term "priming" effect of repeated SKF-38393 treatment. Olanzapine also antagonized the stimulant effects of quinpirole (a D-2-type DA agonist) in animals lesioned as young adults, at doses lower than those necessary to antagonize SKF-35393-induced activity. In addition, olanzapine antagonized apomorphine-induced self-injurious behavior in neonate-lesioned rats in a dose-related fashion. Attenuation of self-injury in this animal model Suggests thatolanzapine should be tested against this symptom in patient populations. [Neuropsychopharmacology 25:224-233] (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

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Documento generato il 25/01/20 alle ore 03:31:22