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Titolo:
Pre-exposure to (+/-)3,4-methylenedioxy-methamphetamine (MDMA) facilitatesacquisition of intravenous cocaine self-administration in rats
Autore:
Fletcher, PJ; Robinson, SR; Slippoy, DL;
Indirizzi:
Univ Toronto, Ctr Addict & Mental Hlth, Sect Biopsychol, Clarke Div, Toronto, ON M5T 1R8, Canada Univ Toronto Toronto ON Canada M5T 1R8 e Div, Toronto, ON M5T 1R8, Canada Univ Toronto, Ctr Addict & Mental Hlth, Dept Psychiat, Clarke Div, Toronto, ON, Canada Univ Toronto Toronto ON Canada Psychiat, Clarke Div, Toronto, ON, Canada Univ Toronto, Ctr Addict & Mental Hlth, Dept Psychol, Clarke Div, Toronto,ON, Canada Univ Toronto Toronto ON Canada t Psychol, Clarke Div, Toronto,ON, Canada
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 2, volume: 25, anno: 2001,
pagine: 195 - 203
SICI:
0893-133X(200108)25:2<195:PT((F>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL SEROTONERGIC NEURONS; NUCLEUS-ACCUMBENS; 3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; EXTRACELLULAR DOPAMINE; NONHUMAN-PRIMATES; D-AMPHETAMINE; SCHEDULE; ECSTASY; SENSITIZATION; BRAIN;
Keywords:
MDMA; cocaine; sensitization; drug abuse; reinforcement; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Fletcher, PJ Univ Toronto, Ctr Addict & Mental Hlth, Sect Biopsychol, Clarke Div, 250 Coll St, Toronto, ON M5T 1R8, Canada Univ Toronto 250 Coll St Toronto ON Canada M5T 1R8 R8, Canada
Citazione:
P.J. Fletcher et al., "Pre-exposure to (+/-)3,4-methylenedioxy-methamphetamine (MDMA) facilitatesacquisition of intravenous cocaine self-administration in rats", NEUROPSYCH, 25(2), 2001, pp. 195-203

Abstract

Pre-exposure to (+/- )3,4-methylenedioxymeth-amphetamine (MDMA) elevates locomotor activity and extracellular dopamine levels in the nucleus accumbens following a cocaine challenge. The present study determined whether MDMA-induced sensitization to the effects of cocaine could be demonstrated in rats self-administering cocaine. Three groups of rats were treated with saline (Sal), 5 mg/kg MDMA (once per day for 10 days; MDMA-5) or 20 mg/kg MDMA (twice per day for 4 days; MDMA-20). Subsequently, spontaneous acquisition of cocaine self-administration was measured in 12 daily 2-h sessions. Duringthese test sessions, two response levers were present. Responses on one lever delivered infusions of 0.1 mg of cocaine; responses on the other lever had no programmed consequences. Group Sal showed a weak preference for the active lever; whereas, group MDMA-20 exhibited a stronger active lever preference. By day 12, the MDMA-20 group earned approximately twice the number of cocaine infusions as those in group SAL. At this time point, more than twice as many rats in group MDMA-20 were taking a minimum of 10 infusions per session, as compared to group Sal. Rats in group MDMA-5 did not seem to differ from group Sal in terms of lever discrimination, number of cocaine infusions, and percentage of rats obtaining a criterion of 10 infusions. These results indicate that pre-exposure to a high dose of MDMA may facilitate acquisition of cocaine self-administration. This dosing regimen of MDMA is likely to release DA and to be neurotoxic to 5-HT neurons. Either or both of these mechanisms could contribute to the ability of MDMA to facilitate cocaine self-administration. [Neuropsychopharmacology 25:195-203, 2001] (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

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Documento generato il 21/01/20 alle ore 00:57:24