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Titolo:
Effects of single and repeated phencyclidine administration on the expression of metabotropic glutamate receptor subtype mRNAs in rat brain
Autore:
Abe, S; Suzuki, T; Ito, T; Yamaguchi, M; Baba, A; Hori, T; Kurita, H; Shiraishi, H; Okado, N;
Indirizzi:
Univ Tsukuba, Inst Clin Med, Dept Psychiat, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan Univ Tsukuba, Inst Basic Med Sci, Dept Anat, Neurobiol Lab, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan Okayama Univ, Fac Educ, Okayama 7008530, Japan Okayama Univ Okayama Japan 7008530 niv, Fac Educ, Okayama 7008530, Japan
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 2, volume: 25, anno: 2001,
pagine: 173 - 184
SICI:
0893-133X(200108)25:2<173:EOSARP>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMISSION COMPUTED-TOMOGRAPHY; INDUCED LOCOMOTOR-ACTIVITY; CEREBRAL BLOOD-FLOW; PREFRONTAL CORTEX; DIFFERENTIAL EXPRESSION; SCHIZOPHRENIC-PATIENTS; NUCLEUS-ACCUMBENS; MESSENGER-RNAS; BINDING-SITES; IN-VIVO;
Keywords:
metabotropic glutamate receptor; phencyclidine; NMDA antagonist; glutamate; schizophrenia; in situ hybridization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Suzuki, T Univ Tsukuba, Inst Clin Med, Dept Psychiat, 1-1-1 Tennoudai, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba 1-1-1 Tennoudai Tsukuba Ibaraki Japan 3058575 Japan
Citazione:
S. Abe et al., "Effects of single and repeated phencyclidine administration on the expression of metabotropic glutamate receptor subtype mRNAs in rat brain", NEUROPSYCH, 25(2), 2001, pp. 173-184

Abstract

Recent animal studies regarding phencyclidine (PCP), which induces psychotic symptoms in humans, have suggested that g-roup II metabotropic glutamatereceptors (mGluRs) represent a novel target for the treatment of PCP psychosis. In the present study, we used in situ hybridization to investigate the gene expressions of the mGluR 1-5 subtypes following single and repeated administration of PCP in rats. A single administration Of PCP (7.5mg/kg, i.p.,) resulted in a significant decrease in the mGluR5 inRNA expression of group I inGluR in the subcortical regions (thalamus (-15%), central gray (-23%), inferior colliculus (-23%), and nucleus accumbens (-10%)) and hippocampal formation (CA1 (-14%), CA2 (-15%), CA3 (-18%), and dentate gyrus (-18%)). After repeated PCP administration for 14 days,, the mGluR2 inRNA expression of group II inGluR in the anterior cingulate cortex (-23%) and the mGluR4 mRNA expression of group III mGluR in the cortical regions (parietal (-11%), temporal (-13%) and entorhinal cortices (-18%)), the caudate putamen (-12%), thalamus (-17%), and subiculum (-25%) were significantly decreased. These results indicate that PCP affects not only group II mGluR but also group I and III of mGluR, and it is of particular interest that mGluR2 subtype is involved in a development of behavioral abnormality following repeatedPCP administration. Single and repeated administrations of PCP independently regulate the expression of mGluR subtypes of mRNA in the brain. [Neuropsychopharmacology 25:173-184,2001] (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

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Documento generato il 20/11/19 alle ore 02:28:31