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Titolo:
Synchronous activity of inhibitory networks in neocortex requires electrical synapses containing Connexin36
Autore:
Deans, MR; Gibson, JR; Sellitto, C; Connors, BW; Paul, DL;
Indirizzi:
Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 ed, Dept Neurobiol, Boston, MA 02115 USA Brown Univ, Dept Neurosci, Providence, RI 02912 USA Brown Univ ProvidenceRI USA 02912 ept Neurosci, Providence, RI 02912 USA
Titolo Testata:
NEURON
fascicolo: 3, volume: 31, anno: 2001,
pagine: 477 - 485
SICI:
0896-6273(20010816)31:3<477:SAOINI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAP-JUNCTIONS; PLEXIFORM LAYER; FREEZE-FRACTURE; RAT NEOCORTEX; CHICK RETINA; NEURONS; CORTEX; INTERNEURONS; EXPRESSION; BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Paul, DL Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Neurobiol, Boston, MA 02115 USA
Citazione:
M.R. Deans et al., "Synchronous activity of inhibitory networks in neocortex requires electrical synapses containing Connexin36", NEURON, 31(3), 2001, pp. 477-485

Abstract

Inhibitory interneurons often generate synchronous activity as an emergentproperty of their interconnections. To determine the role of electrical synapses in such activity, we constructed mice expressing histochemical reporters in place of the gap junction protein Cx36. Localization of the reporter with somatostatin and parvalbumin suggested that Cx36 was expressed largely by Interneurons. Electrical synapses were common among cortical interneurons in controls but were nearly absent in knockouts. A metabotropic glutamate receptor agonist excited LTS interneurons, generating rhythmic inhibitory potentials in surrounding neurons of both wild-type and knockout animals. However, the synchrony of these rhythms was weaker and more spatially restricted in the knockout. We conclude that electrical synapses containing Cx36 are critical for the generation of widespread, synchronous inhibitory activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:49:36