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Titolo:
Presynaptic specificity of endocannabinoid signaling in the hippocampus
Autore:
Wilson, RI; Kunos, G; Nicoll, RA;
Indirizzi:
Univ Calif San Francisco, Dept Mol & Cellular Pharmacol, San Francisco, CA94143 USA Univ Calif San Francisco San Francisco CA USA 94143 rancisco, CA94143 USA Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA NIAAA, Lab Physiol Studies, NIH, Bethesda, MD 20892 USA NIAAA Bethesda MDUSA 20892 Physiol Studies, NIH, Bethesda, MD 20892 USA
Titolo Testata:
NEURON
fascicolo: 3, volume: 31, anno: 2001,
pagine: 453 - 462
SICI:
0896-6273(20010816)31:3<453:PSOESI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPOLARIZATION-INDUCED SUPPRESSION; CALCIUM-CHANNEL INVOLVEMENT; CANNABINOID CB1 RECEPTORS; BETA-GAMMA-SUBUNITS; RAT HIPPOCAMPUS; N-TYPE; SYNAPTIC TRANSMISSION; GABA RELEASE; AREA CA1; MESENTERIC VASODILATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Nicoll, RA Univ Calif San Francisco, Dept Mol & Cellular Pharmacol, San Francisco, CA94143 USA Univ Calif San Francisco San Francisco CA USA 94143 A94143 USA
Citazione:
R.I. Wilson et al., "Presynaptic specificity of endocannabinoid signaling in the hippocampus", NEURON, 31(3), 2001, pp. 453-462

Abstract

Endocannabinoids are retrograde messengers released by neurons to modulatethe strength of their synaptic inputs. Endocannabinoids are thought to mediate the suppression of GABA release that follows depolarization of a hippocampal CA1 pyramidal neuron-termed "depolarization-induced suppression of inhibition" (DSI). Here, we report that DSI is absent in mice which lack cannabinoid receptor-1 (CB1). Pharmacological and kinetic evidence suggests that CB1 activation inhibits presynaptic Ca2+ channels through direct G protein inhibition. Paired recordings show that endocannabinoids selectively inhibit a subclass of synapses distinguished by their fast kinetics and large unitary conductance. Furthermore, cannabinoid-sensitive inputs are unusual among central nervous system synapses in that they use N- but not P/Q-type Ca2+ channels for neurotransmitter release. These results indicate that endocannabinoids are highly selective, rapid modulators of hippocampal inhibition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 19:03:19