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Titolo:
beta 1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex
Autore:
Graus-Porta, D; Blaess, S; Senften, M; Littlewood-Evans, A; Damsky, C; Huang, Z; Orban, P; Klein, R; Schittny, JC; Muller, U;
Indirizzi:
Friedrich Miescher Inst, CH-4058 Basel, Switzerland Friedrich Miescher Inst Basel Switzerland CH-4058 058 Basel, Switzerland Univ Bern, Inst Anat, CH-3000 Bern, Switzerland Univ Bern Bern Switzerland CH-3000 Inst Anat, CH-3000 Bern, Switzerland Univ Calif San Francisco, Howard Hughes Med Inst, Dept Stomatol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Howard Hughes Med Inst, Dept Physiol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Hosp San Raffaele, Sci Res Inst, I-20132 Milan, Italy Hosp San Raffaele Milan Italy I-20132 Sci Res Inst, I-20132 Milan, Italy European Mol Biol Lab, D-69117 Heidelberg, Germany European Mol Biol Lab Heidelberg Germany D-69117 117 Heidelberg, Germany
Titolo Testata:
NEURON
fascicolo: 3, volume: 31, anno: 2001,
pagine: 367 - 379
SICI:
0896-6273(20010816)31:3<367:B1IRTD>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; CAJAL-RETZIUS CELLS; NEURONAL MIGRATION; MUSCULAR-DYSTROPHY; ALPHA-6 INTEGRINS; NEURITE OUTGROWTH; MICE; EXPRESSION; GENE; NEOCORTEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Muller, U Friedrich Miescher Inst, Maulbeerstr 66, CH-4058 Basel, Switzerland Friedrich Miescher Inst Maulbeerstr 66 Basel Switzerland CH-4058
Citazione:
D. Graus-Porta et al., "beta 1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex", NEURON, 31(3), 2001, pp. 367-379

Abstract

Mice that lack all beta1-class integrins in neurons and glia die prematurely after birth with severe brain malformations. Cortical hemispheres and cerebellar folia fuse, and cortical laminae are perturbed. These defects result from disorganization of the cortical marginal zone, where beta1-class integrins regulate glial endfeet anchorage, meningeal basement membrane remodeling, and formation of the Cajal-Retzius cell layer. Surprisingly, beta1-class integrins are not essential for neuron-glia interactions and neuronal migration during corticogenesis. The phenotype of the beta1-deficient mice resembles pathological changes observed in human cortical dysplasias, suggesting that defective integrin-mediated signal transduction contributes to the development of some of these diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:47:18