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Titolo:
Effect of food on the bioavailability of 100-mg Dilantin Kapseals
Autore:
Cook, J; Randinitis, E; Wilder, BJ;
Indirizzi:
Pfizer Global Res & Dev, Dept Clin Pharmacokinet & Pharmacodynam, Ann Arbor, MI 48105 USA Pfizer Global Res & Dev Ann Arbor MI USA 48105 m, Ann Arbor, MI 48105 USA Univ Florida, Coll Med, Dept Neurol & Neurosci, Gainesville, FL USA Univ Florida Gainesville FL USA t Neurol & Neurosci, Gainesville, FL USA
Titolo Testata:
NEUROLOGY
fascicolo: 4, volume: 57, anno: 2001,
pagine: 698 - 700
SICI:
0028-3878(20010828)57:4<698:EOFOTB>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHENYTOIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
7
Recensione:
Indirizzi per estratti:
Indirizzo: Cook, J Pfizer Global Res & Dev, Dept Clin Pharmacokinet & Pharmacodynam, 2800 Plymouth Rd, Ann Arbor, MI 48105 USA Pfizer Global Res & Dev 2800 Plymouth Rd Ann Arbor MI USA 48105 SA
Citazione:
J. Cook et al., "Effect of food on the bioavailability of 100-mg Dilantin Kapseals", NEUROLOGY, 57(4), 2001, pp. 698-700

Abstract

The authors examined the effect of food on the bioavailability of DilantinKapseals in a nonblinded, single 100-mg dose, randomized, crossover trial. Drug was administered after an 8-hour fast and after a high-fat meal. Differences in mean dietary state values were +6% for maximum concentrations (C-max) and -2% for area under the curve. Associated 90% CI were within US Food and Drug Administration criteria, confirming the absence of a food effect. Thus, patients may take 100-mg Dilantin Kapseals without regard to meals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 05:45:56