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Titolo:
Evidence for an involvement of the ammonia-decreasing action of L-argininein suppressing picrotoxin-induced convulsions in rats and its additive action with diazepam
Autore:
Vanaja, P; Jayakumar, AR;
Indirizzi:
Univ Madras, Dr ALM Postgrad Inst Basic Med Sci, Dept Pharmacol & EnvironmToxicol, Taramani 600113, Chennai, India Univ Madras Taramani Chennai India 600113 Taramani 600113, Chennai, India
Titolo Testata:
NEUROLOGICAL RESEARCH
fascicolo: 6, volume: 23, anno: 2001,
pagine: 622 - 626
SICI:
0161-6412(200109)23:6<622:EFAIOT>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE; BRAIN AMMONIA; METABOLISM; SEIZURES; ACID;
Keywords:
L-arginine; picrotoxin; diazepam; ammonia; convulsions;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Vanaja, P Univ Madras, Dr ALM Postgrad Inst Basic Med Sci, Dept Pharmacol & EnvironmToxicol, Taramani 600113, Chennai, India Univ Madras Taramani Chennai India 600113 00113, Chennai, India
Citazione:
P. Vanaja e A.R. Jayakumar, "Evidence for an involvement of the ammonia-decreasing action of L-argininein suppressing picrotoxin-induced convulsions in rats and its additive action with diazepam", NEUROL RES, 23(6), 2001, pp. 622-626

Abstract

The effects of pre- (30 min before challenge) and post-treatment (5 min after challenge) of L-arginine (840 mg kg(-1)) were tested on picrotoxin-induced increase in ammonia concentrations in brain regions (cerebral cortex, brain stem and cerebellum) and the accompanying convulsive responses in adult male rats. The effect of pre- and post-treatment of L-arginine was testedon the action of diazepam against picrotoxin-induced convulsions. Picrotoxin-induced increase in ammonia concentrations in the brain regions was reverted partially by L-arginine pre-treatment. However, L-arginine pre-treatment failed to inhibit convulsions independently and concurrently with diazepam. On the other hand, L-arginine posttreatment reverted ammonia to controllevel in all brain regions. A partial but significant inhibition of convulsions was found in these animals. The effect produced concurrently by L-arginine and diazepam post-treatment was much greater than that produced by these agents independently, These results suggest that brain ammonia has a partial but significant participation in the convulsant action of picrotoxin. L-arginine has produced a partial protection of picrotoxin-induced convulsions by reverting brain ammonia to control level. The data further suggest that the duration of action of L-arginine is considerably short and that L-arginine has an additive anticonvulsant action with diazepam.

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Documento generato il 04/04/20 alle ore 02:26:30