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Titolo:
Developmental expression of fibroblast growth factor (FGF) receptors in neural stem cell progeny. Modulation of neuronal and glial lineages by basic FGF treatment
Autore:
Reimers, D; Lopez-Toledano, MA; Mason, I; Cuevas, P; Redondo, C; Herranz, AS; Lobo, MVT; Bazan, E;
Indirizzi:
Univ Alcala de Henares, Ramon & Cajal Univ Hosp, Dept Res, Histol Lab, Madrid, Spain Univ Alcala de Henares Madrid Spain Dept Res, Histol Lab, Madrid, Spain Univ Alcala de Henares, Ramon & Cajal Univ Hosp, Dept Res, Neurobiol Lab, Madrid, Spain Univ Alcala de Henares Madrid Spain t Res, Neurobiol Lab, Madrid, Spain Univ London Kings Coll, Ctr Dev Neurobiol, London WC2R 2LS, England Univ London Kings Coll London England WC2R 2LS London WC2R 2LS, England
Titolo Testata:
NEUROLOGICAL RESEARCH
fascicolo: 6, volume: 23, anno: 2001,
pagine: 612 - 621
SICI:
0161-6412(200109)23:6<612:DEOFGF>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; ADULT-RAT BRAIN; CEREBRAL-CORTEX; MESSENGER-RNAS; DIFFERENTIAL EXPRESSION; REACTIVE ASTROCYTES; EGF; PROLIFERATION; BFGF; CNS;
Keywords:
stem cells; fibroblast growth factor receptors; basic fibroblast growth factor; differentiation; neural cell lineages; neural development;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Bazan, E Hosp Ramon y Cajal, Dept Invest, Serv Neurobiol, Carretera Colmenar Viejo,Km 9-1, Madrid 28034, Spain Hosp Ramon y Cajal Carretera Colmenar Viejo,Km 9-1 Madrid Spain 28034
Citazione:
D. Reimers et al., "Developmental expression of fibroblast growth factor (FGF) receptors in neural stem cell progeny. Modulation of neuronal and glial lineages by basic FGF treatment", NEUROL RES, 23(6), 2001, pp. 612-621

Abstract

Neural stem cells (NSCs) are self-renewable, multipotential cells capable of differentiating into the three major neural cell types, but the mechanisms which regulate their development are not fully understood, Both basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) promote theproliferation of NSCs. However, studies on the role of FGFs in the differentiation of EGF-expanded NSCs are still incomplete. We have studied the expression of distinct FGF receptors (FGFRs) in the progeny of EGF-expanded NSCs isolated from E15 rat striatum. In situ hybridization analysis and immunocytochemistry showed a developmentally related expression pattern and a cell lineage-specific distribution of these receptors. FGFR1 and FGFR2 were identified in many early precursors and in the oligodendrocyte lineage. The latter receptor was also present in a subpopulation of astrocytes. FGFR3 was detected in a restricted population of early precursors, in oligodendroglial progenitors, and in neurons and protoplasmic astrocytes of late-term cultures. Basic FGF treatment of the progeny of NSCs increased the proliferative rate of precursors and the number of oligodendrocytes generated, whereas the number of differentiating neurons was significantly reduced. Togetherthese data provide evidence that FGFs modulate the development of EGF-expanded NSCs, and that this is at least partly determined by a cell lineage-specific expression of multiple FGFRs.

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Documento generato il 01/10/20 alle ore 16:06:04