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Titolo:
Quantitative evaluation of cerebral metabolites and cerebral blood flow inpatients with carotid stenosis
Autore:
Uno, M; Harada, M; Nagahiro, S;
Indirizzi:
Univ Tokushima, Sch Med, Dept Neurol Surg, Tokushima 770, Japan Univ Tokushima Tokushima Japan 770 ept Neurol Surg, Tokushima 770, Japan Univ Tokushima, Sch Med, Dept Radiol, Tokushima 770, Japan Univ TokushimaTokushima Japan 770 ed, Dept Radiol, Tokushima 770, Japan
Titolo Testata:
NEUROLOGICAL RESEARCH
fascicolo: 6, volume: 23, anno: 2001,
pagine: 573 - 580
SICI:
0161-6412(200109)23:6<573:QEOCMA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; MR SPECTROSCOPY; PROTON; INFARCTION; QUANTIFICATION; STROKE; HUMANS; SPET;
Keywords:
carotid endarterectomy; carotid stenosis; proton magnetic resonance spectroscopy; single photon emission computed tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Uno, M Univ Tokushima, Sch Med, Dept Neurol Surg, Tokushima 770, Japan Univ Tokushima Tokushima Japan 770 rol Surg, Tokushima 770, Japan
Citazione:
M. Uno et al., "Quantitative evaluation of cerebral metabolites and cerebral blood flow inpatients with carotid stenosis", NEUROL RES, 23(6), 2001, pp. 573-580

Abstract

We examined the metabolic and hemodynamic status of patients with severe carotid stenosis and evaluated the effectiveness of carotid endarterectomy (CEA) by comparing pre- and post-operative results of quantitative proton magnetic resonance spectroscopy CH-MRS) and single-photon emission computed tomography (SPECT). Quantitative H-1-MRS and SPECT were performed in 17 patients with severe carotid stenosis before CEA; in 10 patients the examinations were repeated after CEA. There was a significant correlation between thedegree of internal carotid artery (ICA) stenosis and the N-acetyl-aspartate (NAA) concentration, and between CBF and NAA in the basal ganglia. In 10 of the 17 patients (58.8%) we noted a decrease of NAA on H-1-MRS, After CEAin these patients, NAA was significantly increased, and in 7 of 8 patientswhose pre-operative SPECT had indicated impairment of cerebral vasoreactivity, it was improved. Quantitative H-1-MRS and CBF measurements can indicate the severity of metabolic and hemodynamic impairment in patients with severe carotid stenosis, and can help to assess the effectiveness of CEA.

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Documento generato il 19/02/20 alle ore 15:32:51