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Titolo:
Little change in cerebrospinal fluid amino acids in subtypes of multiple sclerosis compared with acute polyradiculoneuropathy
Autore:
Garseth, M; White, LR; Aasly, J;
Indirizzi:
Univ Trondheim Hosp, Dept Neurol, N-7006 Trondheim, Norway Univ Trondheim Hosp Trondheim Norway N-7006 ol, N-7006 Trondheim, Norway Norwegian Univ Sci & Technol, NTNU, N-7006 Trondheim, Norway Norwegian Univ Sci & Technol Trondheim Norway N-7006 6 Trondheim, Norway
Titolo Testata:
NEUROCHEMISTRY INTERNATIONAL
fascicolo: 2, volume: 39, anno: 2001,
pagine: 111 - 115
SICI:
0197-0186(200108)39:2<111:LCICFA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PATHOGENESIS; LESIONS; PLASMA; MS;
Keywords:
cerebrospinal fluid (CSF); multiple sclerosis (MS); blood-CSF barrier; Guillain-Barre syndrome; amino acids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: White, LR Univ Trondheim Hosp, Dept Neurol, N-7006 Trondheim, Norway Univ Trondheim Hosp Trondheim Norway N-7006 Trondheim, Norway
Citazione:
M. Garseth et al., "Little change in cerebrospinal fluid amino acids in subtypes of multiple sclerosis compared with acute polyradiculoneuropathy", NEUROCHEM I, 39(2), 2001, pp. 111-115

Abstract

Levels of free amino acids were determined in randomised, blinded samples of cerebrospinal fluid (CSF) from patients with relapsing-remitting or chronic progressive multiple sclerosis (MS), all in the active phase of disease. The levels were compared with amino acid amounts in patients with an acute polyradiculoneuropathy (Guillain-Barre syndrome (GBS)) and a control population of patients with no known neurological disease or deficit. The data did not indicate any significant changes in amino acid levels between MS subgroups. The only significant differences between MS patients and controls were a modest reduction in glutamate and a slight increase in taurine, but the changes were so small that the biological relevance is dubious. These results contrasted with the marked increases for many amino acids in CSF from patients with acute polyradiculoneuropathy compared with controls. The amino acid profile in cerebrospinal fluid (CSF) does not appear to provide evidence of differential pathology in multiple sclerosis (MS). The increase in hydrophobic amino acids and lysine in CSF from patients with acute polyradiculoneuropathy is consistent with transudation over the blood-CSF barrierfollowing an infection. The increases in glutamine and alanine may reflectincreased nitrogen removal from brain. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:33:59