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Titolo:
Evolution of a molecular switch: universal bacterial GTPases regulate ribosome function
Autore:
Caldon, CE; Yoong, P; March, PE;
Indirizzi:
Univ New S Wales, Sch Microbiol & Immunol, Sydney, NSW, Australia Univ NewS Wales Sydney NSW Australia & Immunol, Sydney, NSW, Australia
Titolo Testata:
MOLECULAR MICROBIOLOGY
fascicolo: 2, volume: 41, anno: 2001,
pagine: 289 - 297
SICI:
0950-382X(200107)41:2<289:EOAMSU>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
GTP-BINDING PROTEIN; SIGNAL RECOGNITION PARTICLE; COMPLETE GENOME SEQUENCE; ELONGATION-FACTOR-G; ESCHERICHIA-COLI; BACILLUS-SUBTILIS; CRYSTAL-STRUCTURE; CAMPYLOBACTER-LARI; MEMBRANE-PROTEINS; CONSERVED GTPASE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: March, PE Univ New S Wales, Sch Microbiol & Immunol, Sydney, NSW, Australia Univ New S Wales Sydney NSW Australia , Sydney, NSW, Australia
Citazione:
C.E. Caldon et al., "Evolution of a molecular switch: universal bacterial GTPases regulate ribosome function", MOL MICROB, 41(2), 2001, pp. 289-297

Abstract

The GTPases comprise a protein superfamily of highly conserved molecular switches adapted to many diverse functions. These proteins are found in all domains of life and often perform essential roles in fundamental cellular processes. Analysis of data from genome sequencing projects demonstrates that bacteria possess a core of 11 universally conserved GTPases (elongation factor G and Tu, initiation factor 2, LepA, Era, Obg, ThdF/TrmE, Ffh, FtsY, EngA and YchF). Investigations aimed at understanding the function of GTPases indicate that a second conserved feature of these proteins is that they elicit their function through interaction with RNA and/or ribosomes. An emerging concept suggests that the 11 universal GTPases are either necessary for ribosome function or transmitting information from the ribosome to downstream targets for the purpose of generating specific cellular responses. Furthermore, it is suggested that progenitor GTPases were early regulators ofRNA function and may have existed in precursors of cellular systems drivenby catalytic RNA. If this is the case, then a corollary of this hypothesisis that GTPases that do not bind RNA arose at a later time from an RNA-binding progenitor that lost the capability to bind RNA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 03:59:11