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Titolo:
Association between uncoupling protein 3 gene and obesity-related phenotypes in the Quebec Family Study
Autore:
Lanouette, CM; Giacobino, JP; Perusse, L; Lacaille, M; Yvon, C; Chagnon, M; Kuhne, F; Bouchard, C; Muzzin, P; Chagnon, YC;
Indirizzi:
Univ Laval, Phys Act Sci Lab, PEPS,Fac Med, Div Kinesiol,Dept Social & Prevent Med, St Foy, PQ G1K 7P4, Canada Univ Laval St Foy PQ Canada G1K 7P4 event Med, St Foy, PQ G1K 7P4, Canada Univ Geneva, Fac Med, Dept Biochem Med, CH-1211 Geneva 4, Switzerland UnivGeneva Geneva Switzerland 4 chem Med, CH-1211 Geneva 4, Switzerland Louisiana State Univ, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USALouisiana State Univ Baton Rouge LA USA 70808 , Baton Rouge, LA 70808 USA
Titolo Testata:
MOLECULAR MEDICINE
fascicolo: 7, volume: 7, anno: 2001,
pagine: 433 - 441
SICI:
1076-1551(200107)7:7<433:ABUP3G>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
BROWN ADIPOSE-TISSUE; SKELETAL-MUSCLE; RESPIRATORY QUOTIENT; ENERGY-METABOLISM; GENOMIC STRUCTURE; HERITAGE FAMILY; THYROID-HORMONE; PIMA-INDIANS; UCP3 GENE; BODY-FAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Yvon, C Univ Laval, Phys Act Sci Lab, PEPS,Fac Med, Div Kinesiol,Dept Social & Prevent Med, St Foy, PQ G1K 7P4, Canada Univ Laval St Foy PQ Canada G1K 7P4 d, St Foy, PQ G1K 7P4, Canada
Citazione:
C.M. Lanouette et al., "Association between uncoupling protein 3 gene and obesity-related phenotypes in the Quebec Family Study", MOL MED, 7(7), 2001, pp. 433-441

Abstract

Background: UCP3 is a mitochondrial membrane transporter that is postulated to uncouple oxidative phosphorylation from ATP synthesis producing heat instead of ATP. Human UCP3 is mainly expressed in skeletal muscle, which plays an important role in energy homeostasis and substrate oxidation. Therefore, UCP3 is a good candidate gene for obesity. Materials and Methods: We analyzed, among 734 subjects from the Quebec Family Study, a new GA repeat microsatellite located in intervening sequence (IVS) 6 (GAIVS6) in UCP3 gene, and two already described restriction fragment length polymorphisms (RFLP) Y210Y(C -->T) and V102I G -->A). Covariance analysis across genotypes for different adiposity, resting energy expenditure, and glucose metabolism variables was undertaken with age and sex, plus body fat and body mass for nonadiposity phenotypes, as covariates. Results: We found strong associations between GAIVS6 and body mass index (p = 0.0001), fat mass (p = 0.0005), percentage body fat (p = 0.0004), the sum of six skinfold thickness (p = 0.0001), and leptin level (p = 0.0001). Homozygote for the GAIVS6 240 bp alleles (15% frequency in QFS) showed higher adiposity than subjects with the GAIVS6 238 bp allele (70% in QFS). The exons, the 5 ' untranslated region (UTR), and the exon-intron junctions of UCP3 gene from subjects homozygote for either GAIVS6 238 bp or 240 bp alleles were sequenced in search for mutations. Variants 5 ' UTR-55C -->T and Y210Y(C -->T) were detected, whereas IVS4-36C -->T was uncovered, but no new exonic or splice junction mutation was observed. RFLP Y210Y(C -->T) was not associated to adiposity in QFS; V102I(G -->A) showed no variation. Conclusion: Our results suggest that some alleles of UCP3 are involved in the etiology of human obesity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 22:41:32