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Titolo:
A vascular connection to Alzheimer's disease
Autore:
Rhodin, J; Thomas, T;
Indirizzi:
Univ S Florida, Coll Med, Dept Anat, Tampa, FL 33612 USA Univ S Florida Tampa FL USA 33612 oll Med, Dept Anat, Tampa, FL 33612 USA Woodlands Med & Res Ctr, Oldsmar, FL USA Woodlands Med & Res Ctr Oldsmar FL USA ds Med & Res Ctr, Oldsmar, FL USA
Titolo Testata:
MICROCIRCULATION
fascicolo: 4, volume: 8, anno: 2001,
pagine: 207 - 220
SICI:
1073-9688(200108)8:4<207:AVCTAD>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-BRAIN-BARRIER; CEREBRAL AMYLOID ANGIOPATHY; FLUID DRAINAGE PATHWAYS; IN-VITRO EVIDENCE; PRECURSOR PROTEIN; HUMAN PLATELETS; BETA; PEROXYNITRITE; MICROVASCULATURE; PATHOLOGY;
Keywords:
Alzheimer's disease (AD); antioxidants; amyloid-beta; cytokine blockers; electron microscopic analysis; endothelium; estrogen; inflammation; intravital video recording; leukocyte transmigration; microcirculation; selective estrogen receptor modulator (SERM) superoxide dismutase;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Rhodin, J Univ S Florida, Coll Med, Dept Anat, 12901 Bruce B Downs Blvd, Tampa, FL 33612 USA Univ S Florida 12901 Bruce B Downs Blvd Tampa FL USA 33612 2 USA
Citazione:
J. Rhodin e T. Thomas, "A vascular connection to Alzheimer's disease", MICROCIRCUL, 8(4), 2001, pp. 207-220

Abstract

Alzheimer's disease (AD) is characterized by a progressive and debilitating dementia in elderly people. The causes of this disease are not known. butmajor risk factors, include old age and a family history of dementia. Down's syndrome, female gender. low level of education. and head injury. There is no known cure for Alzheimer's disease. The disease is characterized by abnormal accumulation of amyloid-beta peptide and the protein Tau in the nerve cells and extracellular space of certain regions of the brain, Cerebral amyloid angiopathy is another marker for Alzheimer's disease, In autopsies,small cerebral arterial blood vessels and capillaries show signs of inflammation. amyloid accumulations, and a focal breach of the blood-brain barrier. This review focuses on the results of recent investigations of vascular responses to infusion of amyloid-beta (1-40). the means of preventing vascular damage. using a live animal (rat) model. and the combination of intravital video recordings of the mesenteric microvascular bed with electron microscopic analyses of the same vascular segments. We propose that the cerebral vascular changes in patient, with Alzheimer's disease probably precede the neuronal damage and dementia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 13:54:18