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Titolo:
The evolution of bacterial LuxI and LuxR quorum sensing regulators
Autore:
Gray, KM; Garey, JR;
Indirizzi:
Univ S Florida, Dept Biol, Tampa, FL 33620 USA Univ S Florida Tampa FL USA 33620 Florida, Dept Biol, Tampa, FL 33620 USA
Titolo Testata:
MICROBIOLOGY-SGM
, volume: 147, anno: 2001,
parte:, 8
pagine: 2379 - 2387
SICI:
1350-0872(200108)147:<2379:TEOBLA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESCHERICHIA-COLI; SALMONELLA-TYPHIMURIUM; PSEUDOMONAS-AERUGINOSA; AUTOINDUCER PRODUCTION; ERWINIA-CAROTOVORA; GENE-TRANSFER; SEQUENCE; PROTEIN; VIRULENCE; ORGANISMS;
Keywords:
intercellular signalling; cell-cell communication; horizontal gene transfer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Gray, KM Univ Washington, Dept Microbiol, Box 357242, Seattle, WA 98195 USA Univ Washington Box 357242 Seattle WA USA 98195 tle, WA 98195 USA
Citazione:
K.M. Gray e J.R. Garey, "The evolution of bacterial LuxI and LuxR quorum sensing regulators", MICROBI-SGM, 147, 2001, pp. 2379-2387

Abstract

Quorum sensing is a widespread form of bacterial communication in which individual cells produce and respond to specific N-acyl homoserine lactone signal metabolites. The different autoinducer synthases that generate these signals and the receptor/activator proteins that mediate the cell's responseto them constitute evolutionarily conserved families of regulatory proteins known as the LuxI and LuxR families, respectively. We have performed a phylogenetic analysis of 76 individual LuxI and LuxR homologues present in diverse members of the Gram-negative Proteobacteria. The results were consistent with an early origin for these regulators during the evolution of the Proteobacteria, with functional pairs of luxI and luxR genes possibly coevolving as regulatory cassettes. In many cases, specific LuxI and LuxR family members appeared to have been inherited horizontally. In particular, those species containing multiple LuxI and/or LuxR homologues usually appeared tohave obtained each individual homologue or functional pair of homologues from an independent source. Because multiple homologues interact to form regulatory cascades, this finding suggests that hierarchical signalling pathways can potentially evolve by the sequential integration of pre-existing regulatory circuits acquired from diverse sources.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 07:15:00