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Titolo:
Evaluation of linear registration algorithms for brain SPECT and the errors due to hypoperfusion lesions
Autore:
Radau, PE; Slomka, PJ; Julin, P; Svensson, L; Wahlund, LO;
Indirizzi:
Univ Western Ontario, Dept Med Biophys, London, ON N6A 4G5, Canada Univ Western Ontario London ON Canada N6A 4G5 London, ON N6A 4G5, Canada London Hlth Sci Ctr, Dept Nucl Med, London, ON N6A 4G5, Canada London HlthSci Ctr London ON Canada N6A 4G5 , London, ON N6A 4G5, Canada Huddinge Univ Hosp, Dept Hosp Phys, Fac Med, Stockholm, Sweden Huddinge Univ Hosp Stockholm Sweden sp Phys, Fac Med, Stockholm, Sweden Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden Karolinska Inst Stockholm Sweden Dept Clin Neurosci, Stockholm, Sweden
Titolo Testata:
MEDICAL PHYSICS
fascicolo: 8, volume: 28, anno: 2001,
pagine: 1660 - 1668
SICI:
0094-2405(200108)28:8<1660:EOLRAF>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; AUTOMATED IMAGE REGISTRATION; ALZHEIMERS-DISEASE; FLUORINE-18-FDG PET; DEMENTIA; TRANSFORMATION; QUANTIFICATION; OPTIMIZATION; TOMOGRAPHY; VALIDATION;
Keywords:
registration; mutual information; segmentation; single-photon emission computed tomography; Alzheimer's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Slomka, PJ Univ Western Ontario, Dept Med Biophys, London, ON N6A 4G5, Canada Univ Western Ontario London ON Canada N6A 4G5 N6A 4G5, Canada
Citazione:
P.E. Radau et al., "Evaluation of linear registration algorithms for brain SPECT and the errors due to hypoperfusion lesions", MED PHYS, 28(8), 2001, pp. 1660-1668

Abstract

The semiquantitative analysis of perfusion single-photon emission computedtomography (SPECT) images requires a reproducible, objective method. Automated spatial standardization (registration) of images is a prerequisite to this goal. A source of registration error is the presence of hypoperfusion defects, which was evaluated in this study with simulated lesions. The brain perfusion. images measured by Tc-99-HMPAO SPECT from 21 patients with probable Alzheimer's disease and 35 control subjects were retrospectively analyzed. An automatic segmentation method was developed to remove external activity. Three registration methods, robust least squares, normalized mutual information (NMI), and count difference were implemented and the effects ofsimulated defects were compared. The tested registration methods required segmentation of the cerebrum from external activity, and the automatic and manual methods differed by a three-dimensional displacement of 1.4 +/- 1.1 mm. NMI registration proved to be least adversely effected by simulated defects with 3 min average displacement caused by severe defects. The error inquantifying the patient-template parietal ratio due to misregistration was2.0% for large defects (70% hypoperfusion) and 0.5% for smaller defects (85% hypoperfusion). (C) 2001 American Association of Physicists in Medicine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:22:45