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Titolo:
Effect of fibre rotation on the initiation of re-entry in cardiac tissue
Autore:
Vigmond, EJ; Leon, LJ;
Indirizzi:
Univ Calgary, Dept Elect & Comp Engn, Calgary, AB, Canada Univ Calgary Calgary AB Canada pt Elect & Comp Engn, Calgary, AB, Canada
Titolo Testata:
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
fascicolo: 4, volume: 39, anno: 2001,
pagine: 455 - 464
SICI:
0140-0118(200107)39:4<455:EOFROT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
RABBIT ATRIAL MUSCLE; CIRCUS MOVEMENT; SPIRAL WAVES; ELECTRICAL-ACTIVITY; FIBER ROTATION; SCROLL WAVES; MODEL; PROPAGATION; REENTRY; TACHYCARDIA;
Keywords:
fibre rotation; cardiac; re-entry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Engineering, Computing & Technology
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Vigmond, EJ Univ Calgary, Dept Elect & Comp Engn, Calgary, AB, Canada UnivCalgary Calgary AB Canada omp Engn, Calgary, AB, Canada
Citazione:
E.J. Vigmond e L.J. Leon, "Effect of fibre rotation on the initiation of re-entry in cardiac tissue", MED BIO E C, 39(4), 2001, pp. 455-464

Abstract

Transmural rotation of cardiac fibres can have a big influence on the initiation of re-entry in the heart, However, owing to computational demands, this has not been fully explored in a three-dimensional model of cardiac tissue that has a microscopic description of membrane currents, such as the Luo-Rudy model. Using a previously described model that is computationally fast, re-entry in three-dimensional blocks of cardiac tissue is induced by a cross-shock protocol, and the activity is examined. In the study, the effect of the transmural fibre rotation is ascertained by examining differences between a tissue block with no rotation and ones with 1, 2 and 3 degrees ofrotation per fibre layer. The direction of the re-entry is significant in establishing whether or not re-entry can be induced, with clockwise re-entry being easier to initiate. Owing to the rotating anisotropy that results in preferential propagation along the fibre axis, the timing of the second stimulus in the cross-shock protocol has to be changed for different rates of fibre rotation. The fibre rotation either increases or decreases the window of opportunity for re-entry, depending on whether the activation front is perpendicular or parallel to the fibre direction. By varying the transmural extent of the S-2, it is found that a deeper stimulus has to be applied to the blocks with fibre rotation to create re-entry. Increasing the transmural resistance also tends to reduce the extent of the S2 required to induce re-entry. Results suggest that increasing fibre rotation reduces the susceptibility of the tissue to re-entry, but that more complex spatiotemporal patterns are possible, e.g. stable figure-of-eight re-entries and transientrotors. Three mechanisms of re-entry annihilation are identified. front catchup, filling of the excitable gap and core wander.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 12:50:38