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Titolo:
Genomic plasticity and melanoma formation in the fish Xiphophorus
Autore:
Froschauer, A; Korting, C; Bernhardt, W; Nanda, I; Schmid, M; Schartl, M; Volff, JN;
Indirizzi:
Univ Wurzburg, Physiol Chem Biozentrum 1, D-97074 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97074 trum 1, D-97074 Wurzburg, Germany Univ Wurzburg, Inst Humangenet, Biozentrum, D-97074 Wurzburg, Germany UnivWurzburg Wurzburg Germany D-97074 entrum, D-97074 Wurzburg, Germany
Titolo Testata:
MARINE BIOTECHNOLOGY
, volume: 3, anno: 2001, supplemento:, 1
pagine: S72 - S80
SICI:
1436-2228(2001)3:<S72:GPAMFI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
XMRK ONCOGENE PROMOTER; FUGU RUBRIPES; GENE; PLATYFISH; ELEMENT; LOCUS; RETROTRANSPOSONS; MACULATUS; TRANSCRIPTION; ORGANIZATION;
Keywords:
Xiphophorus; melanoma; plasticity; instability; Xmrk; retrotransposon;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Volff, JN Univ Wurzburg, Physiol Chem Biozentrum 1, Am Hubland, D-97074 Wurzburg, Germany Univ Wurzburg Am Hubland Wurzburg Germany D-97074 burg, Germany
Citazione:
A. Froschauer et al., "Genomic plasticity and melanoma formation in the fish Xiphophorus", MAR BIOTEC, 3, 2001, pp. S72-S80

Abstract

Melanoma formation in certain interspecific hybrids of the genus Xiphophorus (Teleostei: Poeciliidae) is associated with the overexpression of the Xmrk receptor tyrosine kinase oncogene. The Xmrk oncogene arose by duplication of the pre-existing Xmrk protooncogene in a highly unstable subtelomeric region of the X and Y sex chromosomes undergoing frequent rearrangements including duplications, deletions, amplifications, and transpositions. Some of these rearrangements are likely to be responsible for the overexpression of the Xmrk oncogene in melanoma. The oncogene itself is very unstable in Xiphophorus and is frequently removed by deletion or disrupted by transposable elements. The Xmrk oncogene region displays a high concentration of retroelements not observed in the corresponding Xmrk protooncogene region. Particularly, a retrovirus long terminal repeat-like sequence was amplified in the proximity of the Xmrk oncogene. Additional genes, some of them also duplicated copies, were detected in this region and might be involved in modulating the melanoma's phenotype.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 14:54:01