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Titolo:
Relative base excision repair in Xiphophorus fish tissue extracts
Autore:
Walter, RB; Sung, HM; Obermoeller, RD; Mitchell, DL; Intano, GW; Walter, CA;
Indirizzi:
SW Texas State Univ, Dept Chem & Biochem, San Marcos, TX 78666 USA SW Texas State Univ San Marcos TX USA 78666 hem, San Marcos, TX 78666 USA Univ Texas, MD Anderson Canc Ctr, Dept Carcinogenesis, Sci Pk Res Div, Smithville, TX 78957 USA Univ Texas Smithville TX USA 78957 i Pk Res Div, Smithville, TX 78957 USA Univ Texas, Hlth Sci Ctr, Dept Cellular & Struct Biol, San Antonio, TX 78284 USA Univ Texas San Antonio TX USA 78284 truct Biol, San Antonio, TX 78284 USA
Titolo Testata:
MARINE BIOTECHNOLOGY
, volume: 3, anno: 2001, supplemento:, 1
pagine: S50 - S60
SICI:
1436-2228(2001)3:<S50:RBERIX>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CULTURED GOLDFISH CELLS; DNA-POLYMERASE-BETA; PYRIMIDINE DIMERS; PHOTO-REACTIVATION; INDUCED DAMAGE; BOVINE TESTIS; PHOTOREACTIVATION; SEQUENCE; GENE; PHOTOREPAIR;
Keywords:
DNA repair; alkylating agent; tumorigenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Walter, RB SW Texas State Univ, Dept Chem & Biochem, 419 Centennial Hall,601 Univ Dr,San Marcos, TX 78666 USA SW Texas State Univ 419 Centennial Hall,601 Univ Dr San Marcos TX USA 78666
Citazione:
R.B. Walter et al., "Relative base excision repair in Xiphophorus fish tissue extracts", MAR BIOTEC, 3, 2001, pp. S50-S60

Abstract

To begin characterizing DNA repair capability among Xiphophorus species, we adapted oligonucleotide-based DNA repair assays to extracts of fish tissues. Here, we report the initial results of relative base excision repair (BER) capability among 3 inbred Xiphophorus fish lines representing 2 species(X. maculatus, and X. couchianus), and interspecies hybrid F-1 animals produced by crossing them. Overall, data from uracil-N-glycosylase (UNG)-initiated BER assay (UNG-BER) indicate that brain tissue extracts generally possess higher BER activity than do gill and liver extracts. UNG-BER activitiesin gill and liver extracts were similar. The BER activity in the tissues of F-1 interspecies hybrids followed the activity pattern of the X. couchianus parent in gill and liver extracts, was similar to the X. maculatus parent in brain extracts, but exhibited a reduced repair capacity in gill tissueextracts compared with either parent. We discuss the use of oligonucleotide-based DNA repair assays to elucidate the role that inheritance of DNA repair potential may play in susceptibility to disease and tumorigenesis in the intact organism.

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Documento generato il 13/07/20 alle ore 17:24:47