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Titolo:
Genetic analysis of susceptibility to spontaneous and UV-induced carcinogenesis in Xiphophorus hybrid fish
Autore:
Nairn, RS; Kazianis, S; Della Coletta, L; Trono, D; Butler, AP; Walter, RB; Morizot, DC;
Indirizzi:
Univ Texas, MD Anderson Canc Ctr, Sci Pk Res Div, Smithville, TX 78957 USAUniv Texas Smithville TX USA 78957 i Pk Res Div, Smithville, TX 78957 USA SW Texas State Univ, Dept Chem & Biochem, San Marcos, TX 78666 USA SW Texas State Univ San Marcos TX USA 78666 hem, San Marcos, TX 78666 USA
Titolo Testata:
MARINE BIOTECHNOLOGY
, volume: 3, anno: 2001, supplemento:, 1
pagine: S24 - S36
SICI:
1436-2228(2001)3:<S24:GAOSTS>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR TYROSINE KINASE; CUTANEOUS MALIGNANT-MELANOMA; PLATYFISH-SWORDTAIL SYSTEM; METHYL-N-NITROSOUREA; LINKAGE GROUP-V; TUMOR-SUPPRESSOR; P16 PROTEIN; CDKN2 GENE; ULTRAVIOLET-RADIATION; MOLECULAR MECHANISMS;
Keywords:
Xiphophorus; spontaneous carcinogenesis; UV-induced carcinogenesis; backcross hybrids; CDKN2X;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Nairn, RS Univ Texas, MD Anderson Canc Ctr, Sci Pk Res Div, POB 389,Pk Rd IC, Smithville, TX 78957 USA Univ Texas POB 389,Pk Rd IC Smithville TX USA 78957 TX 78957 USA
Citazione:
R.S. Nairn et al., "Genetic analysis of susceptibility to spontaneous and UV-induced carcinogenesis in Xiphophorus hybrid fish", MAR BIOTEC, 3, 2001, pp. S24-S36

Abstract

Xiphophorus interspecies hybrids provide genetically controlled models of tumor formation. Spontaneous melanomas form in first-generation backcross (BC1) hybrids produced from backcrossing F-1 hybrids derived from the platyfish X. maculatus Jp 163 A and the swordtail X. helleri to the X. helleri parental strain (the Gordon-Kosswig hybrid cross). Nodular melanomas originate in the dorsal fin from cells constituting the spotted dorsal (Sd) pigmentpattern. A parallel genetic cross, with X. maculatus Jp 163 B, exhibits the spotted side (Sp) pigment pattern instead of Sd, and produces BC1 hybridsexhibiting a much lower frequency of spontaneous melanoma formation. Thesehybrids are susceptible to melanoma development if irradiated with UV light as fry. Other hybrids involving these two strains of X. maculatus and different swordtail and platyfish backcross parents also have been investigated as potential tumor models, and show differing susceptibilities to UV-induced and spontaneous melanomas. Genotyping of individual BC1 hybrids from several Xiphophorus crosses has implicated a locus, CDKN2X (a Xiphophorus homologue of the mammalian CDKN2 gene family, residing on Xiphophorus linkage group V), in enhancing pigmentation and the susceptibility to spontaneous and UV-induced melanoma formation in BC1 hybrids from some crosses, but not others. Homozygosity for X. helleri and X. couchianus CDKN2X alleles in BC1hybrids can predispose individuals to melanoma, but this susceptibility ismodified in other crosses depending both on the contributing sex-linked pigment pattern locus from X. maculatus (Sd or Sp), and the genetic constitution of the backcross parent. Xiphophorus BC1 hybrids constitute unique genetic models offering the potential to analyze the contributions of specific genes to spontaneous and induced tumor formation in different, but comparable genetic backgrounds.

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Documento generato il 29/03/20 alle ore 14:59:56