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Titolo:
Pooled umbilical cord blood as a possible universal donor for marrow reconstitution and use in nuclear accidents
Autore:
Ende, N; Lu, S; Alcid, MG; Chen, RF; Mack, R;
Indirizzi:
Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Pathol & Lab Med, Newark, NJ 07103 USA Univ Med & Dent New Jersey Newark NJ USA 07103 Med, Newark, NJ 07103 USA Shanghai Med Univ, Hua Shan Hosp, Dept Med, Shanghai 200052, Peoples R China Shanghai Med Univ Shanghai Peoples R China 200052 00052, Peoples R China
Titolo Testata:
LIFE SCIENCES
fascicolo: 13, volume: 69, anno: 2001,
pagine: 1531 - 1539
SICI:
0024-3205(20010817)69:13<1531:PUCBAA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-FORMING CELLS; HEMATOPOIETIC PROGENITORS; TRANSPLANTATION;
Keywords:
human cord blood; blood bank stored; marrow transplantation; universal donor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Ende, N Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Pathol & Lab Med, 185S Orange Ave, Newark, NJ 07103 USA Univ Med & Dent New Jersey 185 SOrange Ave Newark NJ USA 07103 SA
Citazione:
N. Ende et al., "Pooled umbilical cord blood as a possible universal donor for marrow reconstitution and use in nuclear accidents", LIFE SCI, 69(13), 2001, pp. 1531-1539

Abstract

Human umbilical cord blood has been shown to be an effective source of stem cells for marrow reconstitution in pediatric patients. Unfortunately, thequantity of stem cells obtained from an individual donor can be quite limited in both the total volume and the numbers of stem cells per ml of cord blood. HLA matching further limits the availability, but recent publicationsindicate close matching may be unnecessary. Therefore, if cord blood from different donors can be combined, larger numbers of stem cells can be available for clinical use provided pooling does not produce a negative effect. Storage of single cord blood specimens at 4 degreesC for 10-21 days in gas permeable bags produced an apparent increase in the percentage of immature cells (CD34, CD117, GPA) and mitotic activity (S + G2/M cells) over day 1. With similar storage of pooled specimens there was a further increase in the number of immature colonies cultured, CD34, CD117, GPA, S + G2/M cells. In addition, nucleated red blood cells increased over the mean values obtained from single cord blood samples. Our previous studies have indicated thatlarge numbers of human mononuclear cells are necessary to reconstitute an irradiated animal model. By combining multiple samples of human cord blood,adequate numbers of stem cells could be pooled for use in adults and wouldprovide cells for megadose therapy, including those patients that had accidentally received lethal irradiation. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 14:17:09