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Titolo:
A family-based study of metabolic phenotypes in calcium urolithiasis
Autore:
Tessier, J; Petrucci, M; Trouve, ML; Valiquette, L; Guay, G; Ouimet, D; Bonnardeaux, A;
Indirizzi:
Hop Maison Neuve Rosemont, Ctr Rech Guy Bernier, Montreal, PQ H1T 2M4, Canada Hop Maison Neuve Rosemont Montreal PQ Canada H1T 2M4 , PQ H1T 2M4, Canada
Titolo Testata:
KIDNEY INTERNATIONAL
fascicolo: 3, volume: 60, anno: 2001,
pagine: 1141 - 1147
SICI:
0085-2538(200109)60:3<1141:AFSOMP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL TUBULAR-ACIDOSIS; KIDNEY-STONES; ABSORPTIVE HYPERCALCIURIA; IDIOPATHIC HYPERCALCIURIA; OXALATE NEPHROLITHIASIS; AUTOSOMAL-DOMINANT; RISK-FACTORS; URINE; EXCRETION; DISEASE;
Keywords:
renal stone formers; hypercalciuria; oxalate; genetics; sib pairs; linkage study; kidney stone; urinary calcium excretion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Bonnardeaux, A Hop Maison Neuve Rosemont, Ctr Rech Guy Bernier, 5415 Boul Assompt, Montreal, PQ H1T 2M4, Canada Hop Maison Neuve Rosemont 5415 Boul Assompt Montreal PQ Canada H1T 2M4
Citazione:
J. Tessier et al., "A family-based study of metabolic phenotypes in calcium urolithiasis", KIDNEY INT, 60(3), 2001, pp. 1141-1147

Abstract

Background. A family history increases the risk of kidney stone passage independent of dietary risk factors. However, the metabolic basis for familial aggregation of urolithiasis is unknown. Methods. We evaluated metabolic risk factors in families with at least twosibs with a history of calcium stones. Sibs underwent outpatient evaluations simultaneously, including 24-hour urine collection and oral calcium loading. Phenotypes were compared between affected and unaffected sibs from thesame sibship. Results. Eighty-three sibships comprising 388 sibs (212 affected sibs, 114males and 98 females, and 176 unaffected sibs, 68 males and 108 females) from 71 families were analyzed. Daily urine calcium excretion was higher in affected compared with unaffected sibs (0.64 +/- 0.33 vs. 0.50 +/- 0.22 mmol Ca2+/mmol creatinine, respectively, P < 10(-5)). This corresponded to absolute values of 7.4 +/- 3.9 and 5.1 +/- 2.3 mmol Ca2+/day, respectively, for affected and unaffected males, and 5.4 +/- 2.6 and 4.2 +/- 1.9 mmol Ca2+/day, respectively, for affected and unaffected female sibs. When analyzed by tertile of onset age of stone passage, the differences in urine calcium were only significant in the first two tertiles (with onset age of stone passage < 35 years). The fasting urine Ca2+/creatinine ratio was significantlyhigher in stone formers compared with control sibs (0.46 +/- 0.27 vs. 0.40+/- 0.27, P = 0.04), as was the postcalcium load Ca2+/creatinine ratio (0.57 +/- 0.46 vs. 0.43 +/- 0.41, respectively, P = 0.02). Body mass index wasmarginally significantly higher in stone forming sibs (P = 0.04). Other urine phenotypes, including oxalate, phosphate, magnesium, citrate, urate, sodium, ammonium, and volume, were not associated with stone passage. Conclusion. Increased urine calcium excretion is the only phenotype associated with a kidney stone formation in these French-Canadian families.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 10:20:15