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Titolo:
Immune cell and humoral circuit in prediction of non-small cell lung cancer patients survival after complete resections
Autore:
Kshivets, O;
Indirizzi:
Siauliai Canc Ctr, Dept Surg, LT-5400 Shiauliai, Lithuania Siauliai Canc Ctr Shiauliai Lithuania LT-5400 -5400 Shiauliai, Lithuania
Titolo Testata:
JOURNAL OF TUMOR MARKER ONCOLOGY
fascicolo: 2, volume: 16, anno: 2001,
pagine: 161 - 174
SICI:
0886-3849(200122)16:2<161:ICAHCI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
LAK CELLS; LYMPHOCYTES; CARCINOMA;
Keywords:
non-small cell lung cancer; immunity; survival;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Kshivets, O Siauliai Canc Ctr, Dept Surg, Tilzes 29-14, LT-5400 Shiauliai,Lithuania Siauliai Canc Ctr Tilzes 29-14 Shiauliai Lithuania LT-5400 ia
Citazione:
O. Kshivets, "Immune cell and humoral circuit in prediction of non-small cell lung cancer patients survival after complete resections", J TUMOR M, 16(2), 2001, pp. 161-174

Abstract

Purpose: Influence of immune cell and humoral circuit on life span and 5-year survival (5YS) of lung cancer (LC) patients (L-CP) after complete resections was investigated. Methods: In randomized trial (1987-1998) consecutive cases after complete resections, monitored 108 LCP (males - 94, females -14; pneumonectomy - 45, upper lobectomy - 44, lower lobectomy - 11, upper/lower bilobectomy - 7, middle lobectomy -1) with pathologic stage II-III (stage II - 34, stage III - 74; squamous cell LC - 56, adenocarcinoma - 46, large cell LC - 6; T1 - 38, T2 - 43, T3 - 23, T4 - 4; N0 - 63, N1 - 20, N2 -25; G1 - 30, G2 - 34, G3 - 44) were reviewed. 59 LCP (age = 56.7 +/- 0.9 years; tumor size = 4.3 +/- 0.3 cm; life span: LS=1903.8+/-21.0 days) lived more than 5 years without any features of LC progressing. 49 LCP (age = 56.6+/-1.2 years; tumor size = 4.6+/-0.3 cm; LS = 542.7+/-55.2 days) died because of generalization of LC during the first 5 years after radical procedures. Variables selected for 5YS study were input levels of 64 immunity bloodparameters, sex, age, TNMG, cell type, tumor size. Representativeness of samplings was reached by means of randomization based on unrepeated random selection. Survival curves were estimated by the Kaplan-Meier method. Differences in curves between groups of LCP were evaluated using a log-rank test. Multivariate Cox modeling, multi-factor clustering, structural equation modeling (SEPATH) and Monte Carlo simulation were used to determine any significant dependence. Results: It was revealed that 5YS of LCP (n = 108) aftercomplete resections significantly depended on: 1) level of T-, B- and K-cell circuit; 2) value of monocyte and macrophage circuit; 3) level of humoral immunity; 4) ratio of malignant cell population number to immunity cell subpopulations in integral patient's organism (cell ratio factors); 5) LC characteristics. Structural equation modeling and Monte Carlo simulation confirmed significant relation between 5YS (life span) of LCP after surgery andcell immune subpopulations (chi2 = 7744.820; k 628; T = 2.264; P = 0.024),humoral immunity data (chi2 = 20.328; k = 13; T 3.496; P = 0.0005), cell ratio factors (chi2 = 446.462; k = 65; T = 13.258; P=0.0001 e-9), LC characteristics (chi2 = 69.514; Df = 19; t = 4.520; P = 0.00062e-2).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 08:11:00