Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Sustained ocular delivery of tilisolol to rabbits after topical administration or intravitreal injection of lipophilic prodrug incorporated in liposomes
Autore:
Kawakami, S; Yamamura, K; Mukai, T; Nishida, K; Nakamura, J; Sakaeda, T; Nakashima, M; Sasaki, H;
Indirizzi:
Nagasaki Univ, Sch Pharmaceut Sci, Nagasaki 8528521, Japan Nagasaki Univ Nagasaki Japan 8528521 maceut Sci, Nagasaki 8528521, Japan Kobe Univ, Sch Med, Dept Hosp Pharm, Chuo Ku, Kobe, Hyogo 6500017, Japan Kobe Univ Kobe Hyogo Japan 6500017 m, Chuo Ku, Kobe, Hyogo 6500017, Japan Nagasaki Univ, Dept Hosp Pharm, Sch Med, Nagasaki 8528501, Japan Nagasaki Univ Nagasaki Japan 8528501 m, Sch Med, Nagasaki 8528501, Japan
Titolo Testata:
JOURNAL OF PHARMACY AND PHARMACOLOGY
fascicolo: 8, volume: 53, anno: 2001,
pagine: 1157 - 1161
SICI:
0022-3573(200108)53:8<1157:SODOTT>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALBINO RABBITS; DRUG; ABSORPTION; MEMBRANES; RELEASE; SYSTEM; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Kawakami, S Nagasaki Univ, Sch Pharmaceut Sci, 1-14 Bunkyo Machi, Nagasaki8528521, Japan Nagasaki Univ 1-14 Bunkyo Machi Nagasaki Japan 8528521 Japan
Citazione:
S. Kawakami et al., "Sustained ocular delivery of tilisolol to rabbits after topical administration or intravitreal injection of lipophilic prodrug incorporated in liposomes", J PHARM PHA, 53(8), 2001, pp. 1157-1161

Abstract

To improve the retention time of tilisolol in the precorneal area or vitreous body we prepared, liposomes incorporating the O-palmitoyl prodrug of tilisolol. O-Palmitoyl tilisolol was completely incorporated in the liposomes. After topical administration of O-palmitoyl tilisolol liposomes to the rabbit eye, O-palmitoyl tilisolol rapidly disappeared from the tear fluid. The inclusion of 2 % carmellose sodium slightly prolonged the retention of O-palmitoyl tillsolol in the tear fluid. After intravitreal injection of O-palmitoyl tilisolol liposomes, there was a relatively prolonged retention of O-palmitoyl tilisolol in the vitreous body. At 24 and 48 h after intravitreal injection of O-palmitoyl tilisolol liposomes, the tilisolol concentration in the vitreous body was significantly higher compared with the concentration after intravitreal injection of tilisolol liposomes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:33:24