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Titolo:
Spectrophotometric simultaneous determination of triamterene and hydrochlorothiazide in triamterene-H tablets by multivariate calibration methods
Autore:
Kargosha, K; Sarrafi, AHM;
Indirizzi:
Chem & Chem Engn Res Ctr Iran, Tehran, Iran Chem & Chem Engn Res Ctr IranTehran Iran gn Res Ctr Iran, Tehran, Iran Islam Azad Univ, Sci & Res Branch, Lab Complex 3, Tehran, Iran Islam Azad Univ Tehran Iran i & Res Branch, Lab Complex 3, Tehran, Iran
Titolo Testata:
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
fascicolo: 2, volume: 26, anno: 2001,
pagine: 273 - 279
SICI:
0731-7085(200109)26:2<273:SSDOTA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
WAVELENGTH RANGE; NEURAL NETWORKS; COMPONENTS; MIXTURES; BINARY;
Keywords:
triamterene; hydrochlorothiazide; pharmaceutical analysis; multivariate calibration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Kargosha, K Chem & Chem Engn Res Ctr Iran, POB 14335-186, Tehran, Iran Chem & Chem Engn Res Ctr Iran POB 14335-186 Tehran Iran Iran
Citazione:
K. Kargosha e A.H.M. Sarrafi, "Spectrophotometric simultaneous determination of triamterene and hydrochlorothiazide in triamterene-H tablets by multivariate calibration methods", J PHARM B, 26(2), 2001, pp. 273-279

Abstract

The multivariate calibration methods of partial least-square regression and principal component regression were applied for the simultaneous spectrophotometry determination of triamterene (TRM) and hydrochlorothiazide (HYD) in their mixtures. The parameters of the chemometric procedure were optimized, and the proposed methods were validated with synthetic samples and applied to analyze these drugs in pharmaceutical products with good accuracy and precision. The results were compared with those given by the British Pharmacopoeia (BP) method. The square of the correlation coefficients (R-2) forpredicted TRM and HYD with the proposed method in a test sample were 0.9994 and 0.9992, respectively. The relative standard deviation for commercial tablets in the proposed method and BP standard method were 0.405 and 2.142%, respectively. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 08:01:47